فهرست مطالب

Journal of Applied Organometallic Chemistry
Volume:1 Issue: 1, Feb 2021

  • تاریخ انتشار: 1399/11/13
  • تعداد عناوین: 6
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  • Sunil Gaikwad *, Milind Gaikwad, Pradeep Lokhande Pages 1-8

    We have developed a simple method for the regioselective aromatization of Polysubstituted Cyclohexanone derivatives in the presence of iodine (25 mol %), Pd/C (10Mol%) in dimethyl sulfoxide at 90 °C. , afforded functionalized biphenyls with at least one phenolic hydroxyl in moderate to very good yields. The present protocol contains a cheap catalyst, easy work up, normal reaction conditions, and high selectivity.

    Keywords: Molecular iodine, DMSO, Pd, C, Biaryl phenol, multi substituted cyclohexanone
  • Baliram Hote *, Dyanoba B. Muley, Gajanan G. Mandawad Pages 9-16

    The efficient and facile protocol was developed for the synthesis of 2-styryl-4H-chromen-4-one 3a-i derivatives. The condensation of substituted 2-hydroxyacetophenone with cinnamic acid to obtained (E)-2-acetylphenylcinnamate 2a-i derivatives, which on treatment with base leads to target 3a-i derivatives. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in good to excellent yield applying the current method. All target compounds are characterized by IR, 1H NMR, and 13C NMR spectral data.

    Keywords: Baker-Venkataraman transformation (BVT), Cinnamic acid, 2-styryl chromone
  • Bita Baghernejad *, Mahsa Fiuzat Pages 17-21

    Benzopyranes and their derivatives are of interest due to their wide range of biological and medicinal properties. In this study, 2-amino-4H-pyran derivatives were obtained through a one-step multi-component reaction of aromatic aldehyde, malononitrile and dimedone in the presence of ninhydrin as a catalyst in water with high efficiency and short time.

    Keywords: 2-amino-4H-pyran, multi– component reaction, One-pot, ninhydrin
  • Rahul Kamble *, Milind Gaikwad, Manojkumar Tapare, Shrikant Hese, Shuddhodan Kadam, Ajay Ambhore, Bhaskar Dawane Pages 22-28
    An efficient and convenient method has been developed for the synthesis of 2-amino-5-oxo-4-phenyl-4, 5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives from one-pot multicomponent reaction between 4-hydroxy-2H-chromen-2-one, aromatic aldehydes and malononitrile catalyzed by DTP/SiO2 as an efficient and reusable heterogeneous catalyst. The current method provides adavtages over reported method viz simple operational procedure, easy isolation and recyclability of the catalyst, environmental benign, reduced reaction time and superior yield.
    Keywords: DTP, SiO2, Green chemistry, dihydropyrano[3, 2-c]chromene-3-carbonitrile
  • Vishnu Adole * Pages 29-40
    The rising concerns about the Biginelli reaction are mainly attributable to the therapeutic and pharmacological features of Biginelli adducts, especially dihydropyrimidinones (DHPMs). The DFT framework could be used to explore molecular properties such as molecular structures, molecular energies, ionisation potentials, dipole moments, and electronic parameters. It also contributes to the correlative analysis of theoretical and experimental findings through providing valuable perspectives. Using density functional theory (DFT) at the 6-311++G(d,p) basis set, twelve Biginelli adducts were focused to ascertain various structural and chemical parameters. The important structural parameters such as optimized molecular structures, frontier molecular orbital (FMO) analysis, and molecular electrostatic potential analysis were addressed in the present report. In addition, different quantum chemical parameters have been calculated to gain a deeper comprehension of the molecules' synthetic reactivity. The FMO and quantum chemical exploration revealed that BA7 molecule has a lower HOMO-LUMO energy gap, indicating that charge transfer interactions are inevitable within the molecule. The BA7 molecule was also found to have a higher global softness value than the other derivatives. The absolute hardness of the BA6 molecule, on the other hand, is higher. With a value of 2.3228 eV, the BA3 molecule was revealed to have the highest charge transfer.
    Keywords: Biginelli adduct, 6-311++G(d, p), frontier molecular orbital, Molecular electrostatic potential
  • Shubham Bhagwatrao Biradar, Dnyaneshwar Vithal Narte, Rushikesh Pradip Kale, Kalimoddin Momin, Maroti Sudewad, Kundan Tayade, Dhananjay Palke * Pages 41-47

    A new series of Schiff bases derived from DHA (Dehydroacetic acid) and aromatic primary amines were synthesized and characterized by elemental and spectral (Electronic, IR and 1HNMR) analysis. The signals of 1HNMR spectrum and characteristic peaks in IR spectra are used for the molecular structure elucidation of synthesized Schiff bases. The antimicrobial activities of synthesized compounds have been screened in vitro against Escherichia coli, Staphylococcus aureus, Bacillus subtilis bacterial species, Candida albicans and Aspergillus niger fungal organism and found to exhibit strong antifungal activity than antibacterial activity. Among the studied DHA Schiff base of 2-amino-4,6-dimethylpyrimidine depicted discerning antifungal and antibacterial activities.

    Keywords: Dehydroacetic acid, Schiff bases, Spectral, Biological study