فهرست مطالب

Eurasian Chemical Communications - Volume:5 Issue: 12, Dec 2023

Eurasian Chemical Communications
Volume:5 Issue: 12, Dec 2023

  • تاریخ انتشار: 1402/08/27
  • تعداد عناوین: 6
|
  • M. Artabah Muchlisin, Syafirda Arma&#, Atu Solekhah, Muhammad Naufal Nadhirul Fuadi, Rachma Izza Fawzia, Novia Maulina, Burhan Maarif * Pages 1055-1063
    Pain and inflammation in the joints from cartilage breakdown characterize osteoarthritis (OA), a degenerative disease linked to low estrogen levels. Because phytoestrogens can perform the same role as estrogen, they may be useful in relieving OA-related pain and inflammation. It is well-documented that some plants, like Chrysophyllum cainito L., contain phytoestrogens. To identify the efficacy of a 70% ethanol extract (CLE) and tablet (CLT) formulated from C. cainito leaves in reducing pain perception in male Wistar rats. Acute toxicity tests were initially carried out on the CLE in rats. The analysis was carried out for 14 days, and then a probit analysis was performed to determine the LD50 value. The antinociceptive activity of CLE and CLT was then tested on rats using the writhing test at doses of 4.05, 8.1, and 16.2 mg/200 g BW rat/day for the CLE, and 24.3, 48.6, and 97.2 mg/200 g BW rat/day for the CLT. After 30 minutes of administration of each sample, the rats were induced intraperitoneally with 1% acetic acid and then observed for their stretch for 30 minutes. The LD50 for the CLE was 70.028 g/kg, indicating that it was practically non-toxic. The rats also showed no signs of toxicity qualitatively. Both the CLE and CLT demonstrated antinociceptive activity, with the optimal dose for CLE being 4.05 mg/200 g BW, and the optimal dose for CLT being 48.6 mg/200 g BW, resulting in percentages of writhing inhibition of 80.61 ± 7.3 and 80.62 ± 7.3, respectively. These results indicate that CLE and CLT are safe and have an antinociceptive effect, so they have the potential to be developed as alternative anti-OA drugs.
    Keywords: antinociceptive, Chrysophyllum cainito L, Extract, tablet
  • Devi Eka Juniarti *, Gabriela Kevina Alifen, Satria Aji Prasidha Pages 1064-1071

    Caries removal and cavity preparation are associated with restorative treatment in carious teeth. Cutting dental hard tissue is challenging to remove the carious tissue and maintain the healthy tissue to support the restoration. In recent decades, the laser has been widely used in dental practices and played a significant role in non-invasive treatment approaches. The laser with the highest efficiency for hard tissue and useful for dental caries is the Er:YAG laser, which is approved by the Food and Drug Administration (FDA). This literature review aims to list the benefits of employing Er:YAG lasers in dentistry practices for cavity preparation and caries eradication. More healthy tissue can be preserved with more precision, a clean surface, and a smear-layer-free surface thanks to use the Er:YAG laser to remove cavities. Using Er:YAG laser in dental practice can reduce the risk of infection because it provides a surface decontamination effect and generates less aerosol. Patients will also feel more comfortable and painless during the treatment. Dental practitioners and patients have significantly benefited from cavity preparation and using the Er:YAG laser to remove dental cavities.

    Keywords: Ablation, Caries, Cavity, Dental laser, Er:YAG laser, Human, Health
  • Muhammad Lubis *, Sumaiyah Sumaiyah, Embun Nasution, Ririn Astyka, Masfria Masfria, Hafid Syahputra, Carlos Lase Pages 1082-1095
    One of the plants that potential to develop as an anticancer agent is Duku leaf (Lansium domesticum Corr.). From previous studies, Duku leaf extract had cytotoxic activity against several cancerous cell lines. The aim of this study was to determine the cytotoxic activity of crude and purified extracts of Duku leaf against MCF-7 and HTB-183 cell lines. The crude extract of Duku leaf was obtained using maceration in ethanol absolute. The vacuum liquid chromatography with a gradient mobile phase was performed to obtain the purified extracts. The crude and purified extracts were observed to inhibit MCF-7 and HTB-183 cells using 3-(4,5- dimethyl thiazol 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The antioxidant properties of samples were determined using radical DPPH scavenging activity. The data was collected and analyzed to provide the inhibitory concentration 50 (IC50) and Pearson’s correlation was analyzed to describe the correlation between cytotoxic and antioxidant properties. Five purified extracts were obtained and tested against MCF-7 and HTB-183. The purified extract D has stronger anticancer and antioxidant activities than other samples with IC50 of 56.26 ± 3.11 µg/mL, 70.94 ± 2.92 µg/mL,  and 53.65 ± 1.55 µg/mL, respectively (p < 0.05). We confirmed that cytotoxic activity has a strong correlation with antioxidant properties. Furthermore, the active compounds of purified extract D needed to be investigated and tested against MCF-7 and HTB-183 to explore the possible anticancer mechanisms.
    Keywords: Lansium domesticum Corr, Vacuum liquid chromatography, Cytotoxic, Antioxidant
  • Maming Maming, Fadliah Mubakira, Indah Raya *, Bulkis Musa, Andi Anshar, Erna Mayasari, Yusafir Hala, Syaharuddin Kasim, Andi L., Gemini Alam, Andi Usman, Hasmawati Hasmawati, Hasri Hasri, Andriani Usman, Rizal Irfandi Pages 1096-1116
    This study aims to know how to composite hydroxyapatite-collagen by freeze-drying method, and the characterization of hydroxyapatite-collagen composites using XRD, FTIR, and SEM. Hydroxyapatite nanocrystals are synthesized using the precipitation method by reacting CaO and (NH4)2HPO4 and the freeze-drying method in composite manufacturing by reacting hydroxyapatite nanocrystals with collagen. The results showed that hydroxyapatite nanocrystals can be composite with collagen using the freeze-drying method, and the results of characterization of XRD, FTIR, and SEM hydroxyapatite-collagen composites show the formation of chemical bonds between hydroxyapatite and collagen. The XRD spectrum of HAp-Collagen shows a peak at 2θ 10.45°, showing a physically formed composite. FTIR characterization shows the presence of absorption bands PO43- and OH- from HA, slight wavenumber shifts also occur in C-H, C-N, N-H, and C=O groups which are characteristic of collagen, this indicates that composites are formed physically. SEM characterization shows HAp is perfectly deposited into collagen molecules.
    Keywords: Eggshell, Bone Repair, hydroxyapatite-collagen composite, Nano hydroxyapatite
  • Anita Widiyana, Tri Widiandani, Siswandono Siswodihardjo * Pages 1117-1126
    The development of new breast cancer drugs is carried out through Computer-Aided Drug Design. Molecular docking and the Quantitative-Structure Properties Relationship (QSPR) as a step to obtain more effective compounds, selective, and the most influential physicochemical parameters through structural modification. Structural modification through the addition of acetyl groups caused changes in the biological activity of the compound. The research aimed to discover breast cancer drug prediction and its relationship with QSPR 5-O-acetylpinostrobin derivatives. The anti-breast cancer prediction used AutoDock Tools with the ERα type (PDB: 6V87). The selected parameters include free energy binding and inhibition constants. The physicochemical properties and excretion parameters were determined via online pkCSM and SwissADME. The relationship between physicochemical properties and total clearance was determined based on the QSPR equation with SPSS. The results of molecular docking showed five compounds with free energy binding and minimum inhibition constant values, namely P1, P2, P3, P4, and P5, with free energy binding values of -7.86, -7.77, -7.57, -7.31, and -6.96 kcal/mol and inhibition constant values of 1.73, 2.02, 2.82, 4.37, and 7.88 mM, respectively. The best QSPR equation was (1/CLtot) = 0.130*nRB - 0.034*MR + 0.366*Log P + 1.534 (n = 20, r = 0.761, SE = 0.579, F = 7.331, .sig = 0.003). An increase in nRB and Log P values and a decrease in MR values affect the increase in total clearance. Based on the results of the study, the five 5-O-acetylpinostrobin derivative compounds have the potential to be synthesized and tested further in vitro.
    Keywords: 5-O-acetylpinostrobin, breast cancer, estrogen alpha, In Silico
  • Prakash Palanivelu *, Regidor III Dioso Pages 1127-1139
    A Randomized control pilot study was conducted to investigate the effect of simulation of the Mental Status Examination on skills to interpret findings, level of self-confidence, and satisfaction with learning among nursing students. Two nursing colleges were randomly allocated into interventional and control groups. The data has been obtained from the 20 nursing students of each group. Audio simulation has been administered to the experimental group and lecture method teaching has been administered to the control group. Pre-recorded Case Scenario Audiotapes are used to assess the skills to interpret the alteration in thought, perception, and cognition before the simulation. Student satisfaction and self-confidence in learning scale developed by the National League for nurses, Washington, is also used in this study. SPSS-21 was used to analyze the data and paired ‘t-test was done to identify the effectiveness of the simulation.  The results reveal that both the experimental and control group teaching sessions were found to be significant since the p-value is <0.05. However, in the descriptive statistics experimental group students were more satisfied with the learning and felt more self-confident after the simulation-based teaching of the mental status examination. Thus, the audio-simulation technique was found useful in teaching the mental status examination.
    Keywords: Simulation, mental status examination, Nursing students, self-confidence, satisfaction with learning, innovation in teaching