مجله دانشگاه علوم پزشکی گرگان
سال هشتم شماره 2 (پیاپی 18، تابستان 1385)

Pharmacological studies and traditional medical literature point to the cardiovascular effects of the Citrus aurantium L. (Rutaceae) in many instances. In the present study, we used isolated perfused AV-node of rabbit as an experimental model to determine the effect of various concentrations of essence of Citrus aurantium (0.1-0.3 v/v) on electrophysiological properties of isolated heart. The second goal of the present study was to assess the protective role of essence of Citrus aurantium on arrhythmogenic effects of ouabain. This was a semi-experimental study. We used isolated perfused rabbit AV-nodal preparation, in three groups. In the first group, the effect of various concentration of the Citrus aurantium (0.1, 0.2, 0.3 ml/l) was assesed on the AV-node. In the second and third groups, the effect of Citrus aurantium was tested in the presence of ouabain (0.1?molar) and verapamil (0.1?molar). We used 6 rabbit in each group. Statistical analysis was preformed by SPSS Mean±SE was used in the all results. Our results showed depressant effects of extract of Citrus aurantium on Wenchebach Cycle Length (WBCL), AV Conduction Time (AVCT), Effective and Functional Refractory Periods (ERP & FRP). Rate-dependent properties such as Facilitation and fatigue significantly increased by Citrus.a (0.3ml/l). We had significant increase in the AVCT (32.6±3.6 to 40±6.08 msec) and FRP (147±5.1 to 166.6±3.6 msec) by Citrus.a. We had a protective role of Citrus aurantium on ouabain induced AV-nodal depression. The magnitude of facilitation and fatigue in the concentration of 0.3 C.aurantium was 7.5±0.3 and Conclusion6.5±0.5, respectively. The above results indicated potential inhibitory and antiarrhythmic effect of Citrus aurantium in treating supraventricular tachyarrhythmia.

Hypercholesterolemia is a risk factor for atherosclerosis that responded variably to dietary modification of fat and cholesterol. Previous studies in humans have shown that ingestion of lecithin can alter plasma cholesterol and triglyceride but results were different. The current study was designed to investigate the hypocholesterolemic properties of lecithin on patient with hypercholesterolemia. Sixty one subjects (27 Male, 34 Female) with mean ages 44±14 years old with hypercholesterolemia, was admitted to Mottahari Health Center(Shiraz), randomly assigned to the case (n=31) and control (n=30) groups. Case group received three lecithin capsules (1200 mg) which contain 420 mg Phosphatidylecoline, daily for six weeks. Subject's weight, Body Mass Index (BMI) and serum lipid concentration were measured at the beginning and the end of six weeks. No significant difference were found in mean weight in case group when compared to control group. Also no significant difference were found in mean BMI in case group when compared to control group. Significantly lower mean serum Total Cholesterol, LDL cholesterol, and triglyceride and significantly higher HDL cholesterol were found in case group. In addition mean serum total cholesterol (P<0.05), LDL cholesterol (P<0.05) and TG (P<0.05) decreased and mean serum HDL-Cholesterol (P<0.05) increases significantly in case group vs. control group. This study showed that lecithin could be considered as effective nutrient useful in dietary treatment of hypercholesterolemia.

The prevalence rate of pediculosis capitis is 0.9% to 20.5% in different areas of Iran. This rate in Gorgon rural areas is around 10.8%. According to the complications of this infectious in children, treatment is very important. There are several factors that affect the efficacy of treatment like form of the drug and length of treatment. This study was done to compare the effect of permethrin with co-trimoxazole on pediculosis of female students. This experimental study with infectious of pediculosis in head performed on 200 female students of elementary schools in Gorgan the center of Golestan province in the north of Iran. The patients divided in two groups (permethrin and co-trimoxazole) in permethrin group, the patients used permethrin shampoo with 1% concentration and in co-trimoxazole group, patients used co-trimoxazole tablet (two tablets, twice a day). The cure rate of permethrin and co-trimoxazole were 65% and 59%, respectively. Having bathroom in their home was an important factor affecting the cure rate (p<0.05). according to the higher efficacy of permethrin, we recommend this drug for treatment of pediculosis.

Examinations are among the most important stressors in schools and universities that result to psycho physiological outcomes but these effects on children has not been paid much attention. This study was done to determine the effect of stress of final examinations on the activation of hypothalamus-pituitary-adrenal axis (change of salivary cortisol) and autonomous nervous system (pulse rate) in children. A total of 100 children (50 boys, 50 girls) in 5th grade aged less than 12 years from two primary schools of five educational district in Tehran were chosen randomly. The subjects completed Adolescent’s Eysenck personality inventory. Physical and mental health was reviewed the medical history, clinical examinations and after controlling sleep, food, drug and sport variables, salivary samples and pulse rates were taken five times as follows: once a week before and then three times through mathematics, history and science exams and once a week after passing the exams at 9 to 10 am. Salivary cortisol samples were analysed by ELISA method. Cortisol levels increased significantly during examinations in compare with cortisol levels before and after examinations. Depending to sex, psychoticism, neuroticism and extroversion –introversion variables, only the effect of psychoticism and extroversion –introversion are statistically significant (P<0.05). Also repeated analysis of variance for pulse rate indicated the increase rate of later factor (P<0.05). Final examinations as a stressor resource increase salivary cortisol and pulse rates of children. Personality factors can modulate the effect of examinations on salivary cortisol. Sex also modulates pulse rates increasing during academic examinations.

Migraine is a periodic headache, usually unilateral and mostly pulsating. This disease is seen in about 10% of general population. So far, no applicable and accurate diagnostic test has been introduced and the diagnosis has been made almost clinically and after other etiologies being ruled out. The aim of this study was to evaluate the diagnostic role of visual evoked potential (VEP) in patients with migraine. Forty patients with migraine were enrolled in a prospective, case-control study during the years 2004-2005 in Tabriz Imam Khomeini hospital and underwent the VEP study along with 40 healthy volunteers (as the control group). The mean latency of waves N75, P100, N140 and amplitude of wave P100 were measured and compared between two groups. The frequency of increased mentioned waves was compared as well. The mean latency of wave N140 and the number of its increased values and amplitude of P100 were all significantly higher in patients group (P<0.05). The mean latency of P100 was significantly higher in patients with classic migraine (P=0.05). In spite of the fact that there are some significant differences in the VEP results between the patients and the healthy cases, none (except of the patients with classic migraine) are considered as specific changes for migraine. However, for more definite results, further studies are recommended.

WHO estimated almost 27% of under 5 years children suffered from under-weight. This study aimed are assessing anthropometric indicators (underweight, wasting and stunting) in 0-24 months children at Golestan province and the relationship with the background variables of households. This cross-sectional study was done on 1473 children (under 2 years old) whom resided in urban and rural area. Samplimg method was single stage cluster sampling. Constitutional variables in child’s mothers, age, educational level, job and child’s weight and height are measured by structured questionnair. The data were analysed with chi square, chi square for trend and logistic regression. The under-weight, wasting and stunting (mild to severe) prevalence were 21.4% (CI 95%: 19.3-23.6), 16.5% (CI 95%: 14.7-18.5) and 31.4% (CI 95%: 29.1-33.8) respectively. Maximum sex difference in the malnutrition indicators were seen stunting (boys 14.3%, girls 7.2%) (p<0.05). The prevalence of under-weight, wasting and stunting are positively correlated with increasing the children’s age. The under-weight and stunting linear trend was significant (p<0.05). The risk of under-weight children were 2.8 fold in illitraced mothers relative to mothers with high school diploma (CI 95% for adjusted odds ratio: 1.1-7). The risk was 1.5 fold in stunting (CI 95% for adjusted odds ratio: 0.5-4.3). The under-weight and wasting (moderate to severe) prevalence are increased relatively ANIS study (1998), but stunting prevalence are not increased. The mothers’ illitracy and very low educational level can be suspected risk factors for under-weight and stunting.

Burnout is a syndrom that emerges by mental fatigue and loss of competency. Inappropriate pysical Environment and Professional Equipment may be caused Burnout in nursing. Therefore this study accomplished by object of determination of relationship between Burnout and physical Environment and professional equipments. This is a descriptive –analytical corrolational study. The environment of study was medical sciences hospitals and samples were nursing emploees in 1383-84. The research tools were two questionnaire including Maslach Burnout Inventory (MBI) consisted of three partsincluding: Emotional exhaustion, depersonalization and personal achivement. the next, was pysical Environment and Professional Equipments questionnaire. Total participants were 272 nurses that43.8% of them had high level of emotional exhaustion, also there were a significant relationship between emotional exhaustion, dpersonalization and physical environment (p? 0.05). In adition, there were a significant relationship between severity of emotional exhaustion and dpersonalization with professional equipments (p?0.05). There were a reversed relationship between burnout and professional equipments desirability. This study indicated that most of the samples had high emotional exhaustion and there were relationship with physical environment and professional equipments. Also there were a reversed relationship between burnout and professional equipments desirability.

Despite advances in medical sciences, preeclampsia and eclampsia are still among chief causes of maternal mortality worldwide. In this study, we used classification and regression trees to investigate the role of certain inherent and maternity care factors in severe preeclampsia. This study was done on 1643 pregnant women admitted at 4 hospitals in Iran with one of the 53 maternity complaints were enrolled in this study during 2005. Variables of socioeconomic status, history of pregnancy and diseases, health care visits numbers awareness of warning signs, and the body mass index before pregnancy were recorded in the analysis model as predictors, and preeclampsia severity was entered as the dependent variable. A non-parametric method, known as the classification and regression tree was used to predict the studied consequence. Model validation was done using subsets of the study sample. The results were compared with logistic regression analysis. The incidence of preeclampsia among the studied patients was 5.2%. In model 1, variables of frequent headaches and epigastric pain during pregnancy, the number of previous pregnancies, and the amount of maternal care received were predictive of severe preeclampsia. In model 2, only frequent headaches and the number of previous pregnancies were found predictive. Sensitivity for model 1 and 2 was 47.8% and 39.1%, respectively, and specificity was 96.8% and 93.6%, respectively. In logistic regression analysis, only frequent headache was related to severe preeclampsia (OR=2.5, CI 95%: 1.3-5.0). This study showed that using of variables that can be measured during maternity care visits to predict severe preeclampsia. Regarding the simple interpretation of tree models and their application in clinical decision making, which can be used in different levels of the health care system.

Dyslipidemia and smoking are among the most important medical problems in human society. Their share in the mortality of coronary heart disease (CHD) has led to multiple investigations about them. This study was done to determine the prevalence of dyslipidemia and the effect of cigarette usage on it. This epidemiological cross-sectional study was carried out on 9632 persons selected randomly in Tehran urban with a minimum age of 20 years and over. We measured fasting blood sugar, blood sugar 2 hours after 75 grams oral glucose, triglyceride, total cholesterol, LDL cholesterol, HDL cholesterol. Degree of physical activity was registered according to Lipid Research Clinics classification. Anthropometrics data, social condition, family history and smoking exactly delineated. Our patients were divided into: those having normal lipid profile and primary dyslipidemia (without any risk factor for dyslipidemia) and secondary dyslipidemia (having one or more risk factors such as diabetes mellitus). ANOVA, t.test, and logistic were used to analyze the level of significance. Our population sample consisted of 5619 female and 4013 male. 68.5% of our cases had dyslipidemia. 65.8% of females and 72.3% of males had at least one type of dyslipidemia. There were 1085 smokers (11.4%) that 73.2% of them were dyslipidemic. With comparing smokers to nonsmokers shows that in smokers HDL.cholesterol, LDL.cholesterol and total cholesterol had decreased and triglyceride increased (p<0.05). Tehran population suffers from dyslipidemia. Large number of secondary dyslipidemia and smoking highlighted the importance of education to overcome to these preventable and modifiable factors.

Mycobacterium marinum is the etiologic agent of fish Mycobacteriosis and fish tank granuloma in human in this study our objective was to determine of the fish tank granuloma in Fishermen and Mycobacterium marinum infection in Caviar fishes in Ashorade, in the Golestan province of Iran south east Caspian Sea border. Any suspected lesions in 387 subjects of Fishermen and 113 autopsy samples from gills of fish of Caviar were obtained and cultured in Lowenstein Jensen media. The mycobacterial species were determined by conventional biochemical tests. No fish tank granuloma was proved in human, but 11 (9.73%) strains of Mycobacteria were isolated from Caviar fishes, that only 2 strains (1.76%) belong to M.marinum. This study showed that was low prevalence any cases of fish tank granuloma and infection due to M.marinum in Caviar fish in this Region.