فهرست مطالب

Iranian Journal of Nuclear Medicine
Volume:3 Issue: 2, 1995

  • تاریخ انتشار: 1374/06/20
  • تعداد عناوین: 7
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  • هروز فاتح، علی ستاری، محمد شفیعی، براتعلی اکبری، حسین آفریده، محمد حاجی سعید صفحات 41-49
    The radioisotope 67Ga (T 1/2 = 78 h) in extensively used as single photon marker for detecting the presence of malignancy and the diagnosis of inflammatory diseases. The high tumor specificity of carrier-free 67Ga make it one of the most interesting radionuclides in nuclear medicine for in vivo scanning studies.
    67Ga is a cyclotron produced radioisotopes and is one of the radiopharmaceuticals which is produced at our center. An enriched 68Zn cyclotron target design has been developed for the large-scale production of carrier-free 67Ga with -<5 percent 66Ga contamination as one of the impurities. The advantage of high 67Ga yield from proton beam bombardment of enriched Zinc is somewhat to our disadvantage due to the high price of enriched Zinc. Due to this problem another alternative method for Ga-67 production was sought. Our theoritical and experimental studies have been resulted to production of 67Ga by irradiating natural Zinc with deuteron beam. The production of the radiopharmaceutical is achieved by two steps.
    1) Deuteron bombardment of natural Zine target in the cyclotron and subsequent production of Ga-67.
    2) Chemical processing which involves the separation of 67Ga from target material. After quality control testing, the produced 67GaCI3 is converted to citrate and as a sterile and pyrogen free product, it is ready for human use.
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  • M. Saghari, M. Amoui, R. Najafi, G. Shabani, F. Esfahanian Pages 4-12
    Twenty-one patients with medullary thyroid carcinoma were studied prospectively with Tc-99m (V) DMSA after surgery. Pentavalent DMSA scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. Finally, seven patients with surgical or other imaging documentation were selected for this paper. Most of these patients were asymptomatic. Six patients had hypercalcitonemia and serum calcitonins was not measured in one patient. Whole body scan with Tc-99m (V) DMSA demonstrated abnormal radiotracer uptake in all patients locating in the neck (3 cases), mediastinum (5 cases), bone (2 cases), liver (1 case) and thyroid lobes (2 cases). This preliminary study with the locally developed Tc-99m (V) DMSA showed that it is a useful imaging agent for localization of metastatic lesions in asymptomatic patients with medullary thyroid carcinoma and high serum calcitonine.
  • M. Eftekhari, F. Akhzari Pages 13-20
    Tc-99m-MIBI is an isonrtrile derivative used for evaluation of myocardial perfusion in recent years. In this preliminary report, 7 patients with coronary artery disease are evaluated with Tc-99m-MlBl stress planar and sped studies. Good correlation with coronary angiography is observed in these cases.In view of inherent technical problems present with thallium 201, Tc-99m-MIBi is a good alternative in evaluation of myocardial perfusion.
  • Ali. A. Yaraghchi, Reza. Najafi Pages 21-33
    This article will review the essential chemical structure of IDA derivatives and their biokinetic characteristics as the hepatobiliary agents. The article also presents the procedures of Synthesis, formulation and Quality control of mebrofenin (BRIDA) as a 99mTc-Radiopharmaceuticai kit which is produced in Radioisotope Division of N.R.C. 99mTc-BRiDA has extremely low renal excretion and hence greater hepatic specificity. In addition, the BRIDA is much more resistant to Markedly elevated levels of bilirubin rather than the other IDA''S analogs.
  • B. Fateh, A. Sattari, M.Shafti, A.Akbari, H.Afarideh, M.Hamji Saeed Pages 41-49
    The radioisotope 67Ga (T 1/2 = 78 h) in extensively used as single photon marker for detecting the presence of malignancy and the diagnosis of inflammatory diseases. The high tumor specificity of carrier-free 67Ga make it one of the most interesting radionuclides in nuclear medicine for in vivo scanning studies.67Ga is a cyclotron produced radioisotopes and is one of the radiopharmaceuticals which is produced at our center. An enriched 68Zn cyclotron target design has been developed for the large-scale production of carrier-free 67Ga with -<5 percent 66Ga contamination as one of the impurities. The advantage of high 67Ga yield from proton beam bombardment of enriched Zinc is somewhat to our disadvantage due to the high price of enriched Zinc. Due to this problem another alternative method for Ga-67 production was sought. Our theoritical and experimental studies have been resulted to production of 67Ga by irradiating natural Zinc with deuteron beam. The production of the radiopharmaceutical is achieved by two steps.1) Deuteron bombardment of natural Zine target in the cyclotron and subsequent production of Ga-67.2) Chemical processing which involves the separation of 67Ga from target material. After quality control testing, the produced 67GaCI3 is converted to citrate and as a sterile and pyrogen free product, it is ready for human use.
  • [Tc-99m-PERTECHNETATE IN EVALUATION OF MECKEL'S DIVERTICULUM]
    Armaghan Fard Esfahani Pages 50-56
    Meckel''s diverticulum is a common congenital disorder which may result in Gl bleeding. For definite diagnosis before surgery, radiographic procedures such as small intestine barium studies are not greatly successful; on the other hand Tc-99m-Pertechnetate imaging is a physiologic and noninvasive method with high sensitivity and specificity. In this report, three patients with rectorrhagia, who had positive Tc-99m-Pertechnetate studies but otherwise negative evaluations, are presented. The usefulness of isotopic procedures in evaluation of Meckel''s diverticulum is reviewed.
  • Richard P. Spencer, Mozafareddin K. Karimeddini, Prasanta Karak Pages 1-3
    At 30 minutes after intravenous administration of the glomerular renal agent TC-99m-DTPA, both right and left lateral views were obtained. We analyzed the ratio of optical densities (behind the ureter/In front of the ureter). In patients without gross renal failure or retroperitoneal disease, the ratio was always less than 1 (range 0.38 to 0.95, mean 0.68). This represents greater perfusion of the Intestine and anterior organs as compared with the retroperltoneum. Since the posterior/anterior ratio can be readily determined by computer processing or by measurement of optical density of the film, It was suggested that this might be an approach for detecting increased retroperitoneal permeability in diseases of that area or possibly In cases of renal disorders.
  • Hooshang Mohammadi, David N. Greyson, J. P. Wadded Pages 4-14
    Progressive loss of bone mineral density around the femora! component of total hip replacement continues to pose a threat to long term prosthetic survival. A linear study was undertaken to measure bone mineral density on a monthly basis following total hip arthroplasty in 11 male patients. The opposite femur was used as the control measurement. Bone mineral density was unchanged at two months following surgery but demonstrated significant decrease as compared to the non-operated side at three months and thereafter. There appears to be a continually progressive reduction in bone mineral density values In most zones up to six months. Initial loss of bone mineral density may reflect a change In vascularity of perlprosthetlc bone with progression to mechanical stress shielding. Further study of this phenomenon utilizing both cemented femoral stems and stems coated with bloactlve ceramic appears to be warranted. Keywords: bone mlnearl density, osteoporosis, Gruen zones, orthoped software, dual energy x-ray absorptiometry, total hip arthroplasty