مجله غدد درون ریز و متابولیسم ایران
سال سیزدهم شماره 3 (پیاپی 57، شهریور 1390)

Considering the importance of quality of life (QoL) affected in chronic diseases including diabetes, this study conducted to evaluate health-related quality of life in patients with type 1-diabetes.

In this cross-sectional study, 150 patients with type 1 diabetes were enrolled from the Institute of Endocrinology & Metabolism. A quality of Life questionnaire validated previously for assessment of QoL in people with type-1 diabetes in Iran was used. The questionnaire included 20 questions in five areas of social relationships, emotional, daily activity, academic performance and treatment.

Mean age of the subjects and duration of disease were 22.14±6.84, 8.97± 7.14 years respectively. The mean score for general quality of life was 70.70±13.95 in men and 67.27±11.87 in women. There was no significant difference in general quality of life between men and women. However, regarding treatment, the quality of life in men (65.64±16.65) was higher than in women (P<0.05). General quality of life was significantly correlated with duration of diabetes and type of insulin. In patients treated with insulin-analogues, general quality of life and areas of emotional, social relationships, academic performance and treatment were better.

To conclude, comprehensive diabetes care, including mental health counseling and structured patient education programs might improve QoL in Iranian patients with type 1 diabetes.

The aim of this study was to investigate the association between fructose intake and cardiovascular disease risk factors in Tehranian adults.

This study was conducted using data from adults, aged 19-70 years, who participated in the third phase of Tehran Lipid and Glucose study. Dietary data were collected using a validated semi-quantitative food frequency questionnaire with 168 food items. The sum of natural dietary fructose in fruits and vegetables, and fructose in industrialized foods containing added sweeteners, was calculated as total dietary fructose.

Forty-five and fifty-five percent of participants were men and women, with mean ages of 40.5±13.6 and 38.6±12.8 years, respectively. Mean dietary intakes of total fructose were 46.5±24.5 g/d in men and 37.3±24.2 g/d in women. Significant positive associations were observed between dietary fructose intake and body mass index (β=0.03 and 0.11, p<0.001, in men and women respectively), systolic blood pressure (β=0.09 and 0.12, p<0.01, in men and women respectively), diastolic blood pressure (β=0.13 and 0.80, p<0.01, in men and women respectively) and fasting blood glucose in men (β=0.01, p<0.05).

Dietary fructose intake may have adverse effects on cardiovascular disease risk factors.

Autoimmune thyroid diseases (AITD) are common and it is important to identify the genetic determinants. The aim of this study was to assess the relationship between two polymorphisms of Thyroid Peroxidase gene (TPO) and serum level of Anti-TPO titer in an Iranian population.

We selected 184 individuals from Tehran Lipid and Glucose Study, categorized as the Anti-TPO- (n=72) and Anti-TPO+ (n=112) groups. Inclusion criteria for cases was Anti-TPO and Anti-Tg>100U/L with a history of hypothyroidism. Anti-TPO levels in subjects were measured by the ELISA kit. Genomic DNA was extracted using Salting-out/Proteinase K method. Polymorphism detection of Exon 8 and 12 was done using the PCR-RFLP method. The PCR products were incubated with restriction enzymes SacII and BsrI, respectively.

The C allele frequency of C2145/T polymorphism Exon 12 (rs732608) was observed in 71.2% of patients and in 28.8% of normal individuals. This allele was significantly associated with increased levels of Anti-TPO [(T 140±330 pmol/L; vs. C 436±380 pmol/L; P<0.001), (OR: 9.2)]. The G1193/C was not associated with the level of serum Anti-TPO in this study.

We demonstrated that the C allele polymorphism in C2145/T exon 12 is associated with high levels of serum Anti-TPO and that carriers of this allele are predisposed to disease 9.2 times more than those who do not have A allele.