مجله علوم پزشکی پارس
سال نهم شماره 3 (پیاپی 17، پاییز 1390)

Oxidation of low-density lipoprotein (LDL) has been strongly implicated in the pathogenesis of atherosclerosis. The use of antioxidant compounds in dietary food stuff include vitamin E and herbal extract such as Walnut (Juglans regia L.) husks hydroalcoholic extract (W) may lead to the inhibition of production of oxidized LDL and may decrease both the development and the progression of atherosclerosis. The present work investigated the effects of W on LDL oxidation induced-CuSO4 quantitatively in vitro. Fasting blood samples from normal people after an overnight fasting were collected and then LDL was isolated. LDL was incubated without CuSO4 as control and incubated with CuSO4 and several concentration of W (0.2, 2 and 20 µg/ml); and measured the formation of conjugated dienes, lag time and Malondialdehyde (MDA). Inhibition of this Cu-induced oxidation was studied in the presence of several concentration of W. It was demonstrated that W is able to decrease CuSO4-induced LDL oxidation. Walnut (Juglans regia L.) huske extract showed an increase rate of 87%, 178% and 202% lag time at concentrations ranging from 0.2 µg/ml to 20 µg/ml, respectively. The inhibitory effects of the W on LDL oxidation were dose-dependent at concentrations ranging from 0.2 µg/ml to 20 µg/ml. This study showed that W prevented the oxidation of LDL in vitro and it may suggest that they have the similar effect in vivo.

Some of the athletes use oxymetholone as doping drug. Excessive consumption of oxymetholone cause abnormalities such as lung cancer, ovarian cycle irregularities, liver cancer and adenoma in the renal tubules. The aim of this study was to investigate effect of oxymetholone 0n infant rat kidney. In this experimental study, 30 pregnant rats, divided into control, sham and experimental groups. For experimental group 10 mg oxymetholone and for sham group 10 mg DMSO intraperitoneally injected for 15 days.On first day of delivery infants were weighted, and then dissected. Parameters such as weight, length, width and thickness of the kidneys were measured. Tissue sections were Prepared and then examined under the microscope. Results was analyzed by using of SPSS software and ANOVA test. The results showed that infants weight, the weight, length, width, thickness of kidney and diameter of glomeruli, thickness of cortex and medulla in the experimental group compared with the control group has increased significantly (p <0.05). But the diameter space between the glomerular has decreased. Also, pathological changes such as glomerular cell proliferation, necrosis in cortical tubules and cast forming in the tubules were observed. in this study oxymetholone has been used, causes pathologic changes on renal tissue and increase body weight and kidney weight in infant rat.

Substance abuse have crossed many social, economic, and geographical borders today, and is among major health problems that endanger a multitude of population groups including the pregnant mothers because of their untoward maternal and fetal outcomes. This study was conducted to determine the prevalence of substance abuse and maternal, fetal outcomes. A descriptive and analytic cross-sectional study (October 2006 – December 2007) was conducted on 4647 women who had the criteria for admission to labor wards of educational hospital of Birjand -Iran. Data was collected by questionnaire. The obtained data was statistically analyzed by SPSS software using Descriptive statistical and Logistic regression tests at the significant level (α<0.05). The results showed that the prevalence of addiction among pregnant women was 0.69% and The mean age of addiction women was 29.4 ± 1.32 years and 45.5% were in 20-29 years. In addiction group, 11.4 abruptio placenta, 10% still birth and 37.6% fetal distress was reported. The mean of Gestational Age was 34.6 ± 1.34 weeks and premature delivery was significantly more common in the group of pregnant addicts (31.3 vs. 7.1%). Addiction pregnancies present a small but high-risk group according to perinatal outcome. Appropriate obstetric and neonatal care can reduce the rate of complications in these pregnancies and improve perinatal outcome. Therefore, preventive educational programs during pregnancy should focus on reduction or replace of using such Substance with safe drugs.

The intent of the present study was to compare attachment styles and parental bonding in patients diagnosed with obsessive-compulsive disorder, generalized anxiety disorder and depression. The main hypothesis of the study was that the three clinical groups could be discriminated on the basis of attachment styles. This study is on the basis of causal-comparative type and All patients seeking treatment at government and private psychiatric clinics in ardebil from Shahrivar 1388 to Bahman 1388 comprised the study population. A sample of 38 patients given a diagnosis of Generalized anxiety disorder (GAD), 36 patients with a diagnosis of Obsessive-compulsive disorder (OCD), and 36 patients with a diagnosis of depression that patients responded to questionnaires on attachment style Brennan, Clark, and Shaver, parental bonding Parker, Tupling, and Brown, anxiety and depression Beck and Steer. Data was analyzed using ANOVA and tukey test. Findings revealed significant differences among the three clinical groups on the basis of attachment style and parental bonding (p<0/05). Results showed that three attachment styles from among, preoccupied and dismissing attachment styles connected with anxiety and temperamental disorders and attachment style reports little between in disorders.

This research was conducted to study the effectiveness of cognitive intervention on reported- pain intensity and changes in heart rate and blood oxygen saturation level of children with cancer under the LP/IT. Another goal is the study of the relationship between pain and changes in heart rate and blood oxygen saturation level contributed to LP/IT. This research was a pretest-posttest experimental design with control group. 41 child–parent pairs were selected and randomly assigned to either an experimental or a control group. Children were visited twice. In the first visit, both groups were under routine hospital care and in the second visit, the experimental group received cognitive intervention and the control group received routine hospital care. Data were collected by demographic questionnaire, Oucher Scale and pulse oximeter device and analyzed with Analysis of Covariance and Pearson correlation tests. Results showed that group effect is significant and intervention had been effective in reducing reported-pain intensity, decreasing heart rate and increasing blood oxygen saturation level during LP/IT. There is a significant positive correlation between reported-pain intensity and changes in heart rate and a significant negative correlation between reported-pain intensity and changes in blood oxygen saturation level. Cognitive interventions are effective in reducing reported-pain intensity, decreasing heart rate and increasing blood oxygen saturation level during LP/IT. We recommend that to use cognitive intervention in pain management and reducing physiological changes.

A large number of researchers indicate that numerous mental difficulties can be improved and reduced through exercise eg anxiety and depression reduction, self-esteem increase, physical symptom improvement, social popularity. The goal of this research was, Survey Mental Health In faculty’s Members Of Physical Education And Non In Islamic Azad University. The method was descriptive and analytical, 600 faculty s Members Of Physical Education and non Physical Education with cluster and stage sampling random were selected as samples from Islamic Azad University in Iran.. So General Health questionnairer-28 (GHQ 28) were given to the subjects and after filled out, they were collected. To analyzed the data, descriptive and inferential statistical (t- Test) were used. The result of this research show that there is a meaningful between Depression, Social dysfunction and Anxiety of faculty’s Members Of Physical Education and non but there is no difference in somatization. The rate of Depression and Anxiety are low in faculty s Members Of Physical Education than non. Since the sport as a tool to maintain physical and mental health and prevention of mental disorders is considered with regard to employment conditions and greater communication with the faculty of physical education physical activity depression and anxiety than their less and enjoy good mental health Therefore non-physical education teachers participate in an exercise program is necessary.

with human society developments, health systems confront to new needs that should be met. Whereas customers compare services quality with their expectations, therefore we designed this research for recognizing the gap between client expectations and perceptions from primary health services quality in Gorgan health center. in this analytical survey 225 Gorgan primary health services recipient were studied via stratified random sampling. SERVQUAL questionnaire was used for measuring services quality expectations and perceptions in five dimensions, tangibles, reliability, responsiveness, assurance, and empathy. Data were analyzed in SPSS 16 software environment with descriptive statistic tests and wilcoxon test. Client's age range was 14-57 year and females formed 89.7 present of them. The gap between expectations and perceptions from quality of primary health services was statistically significant (P<0.05). We found the maximum gap in reliability dimension (-1.47) and minimum gap in tangibles dimension (-1.11). Between 22 items of questionnaire, the maximum and minimum gap was found in staff belief about effectiveness of services and staff appearance respectively. there were considerable quality gap in all dimensions. Because of shortage in equipments and resources, recognition of customer's expectations and perceptions could help managers to improve quality with revision and correction of organization process.

Due to the fast growth of population and its destructive effects on different parts of society and the fact that men does not play a significant role in family planning, this study was conducted to investigate the effects of education through health Belief Model on knowledge and attitude of male teachers in Marvedasht about family planning. it was a quasi experimental research. It was a kind of before and after research. 90 male teachers were evaluated by a questionnaire including personal, attitudinal, and knowledge-estimating questions. The education was done using pamphlets and question- answer meetings according to health belief model. The results were analyzed using t-tests, χ2, and Pearson and Spearman correlation. The results of the t-tests between the scores of awareness and attitude before and after training the teachers under study show that there was a significant statistical difference before and after the training program (P<0.001). Moreover, there was correlation between awareness and attitude scores of the individuals as well as the variables of the individual's age, their wive's age, and the number of children, job, and their wive's level of education. Education can increase the knowledge and change the attitudes of the individuals about family planning. Finally, it is suggested that the educational programs related to family planning which are specially designed for men be placed in the agenda of the health officials of our country.