Journal of Advanced Periodontology and Implant Dentistry
Volume:4 Issue: 2, Jul 2012

Background and aims. The role of genetic factors and oxidative damage in the etiopathogenesis of periodontal disease is well documented in the literature. The micronucleus test is a sensitive method that indicates DNA damage. The aim of the present study was to investigate the micronuclei frequency in different forms of periodontitis in comparison with healthy controls. Materials and methods. Micronuclei frequency was analyzed in the peripheral lymphocytes of 10 patients with chronic periodontitis (CP), 10 patients with generalized aggressive periodontitis (GAP) and 10 healthy controls. Various clinical parameters like the probing depth, clinical attachment level, and percentages of sites with bleeding and plaque were recorded. After the slides were processed, they were stained with 5% Geimsa solution and 1000 cells per sample were counted for the presence of micronuclei. Results. The mean micronuclei observed in the control group, CP group, and GAP group were 9.8, 10.1 and 9.9, respectively. The differences between the groups were not significant (P=0.978). Conclusion. The results indicated that the cytogenetic damages in the periodontitis groups were not different from those in the control group. The role of cytogenetic damage in peripheral blood cells may have a limited prognostic value in the etiopathogenesis of periodontal tissues and further studies are necessary to assess cytogenetic damage in periodontal tissues to clarify local tissue destruction in periodontal disease.

Background and aims. The accelerating effect of plasma rich in growth factors in the healing of extraction sockets has been shown by some studies. The aim of the present investigation was to evaluate the effect of deproteinized bovine bone matrix (DBBM) with and without plasma rich in growth factors (PRGF) in canine extraction socket. Materials and methods. Distal roots of second and third upper premolars were extracted bilaterally in six mongrel dogs. Buccolingual (BL) and apico-coronal (AC) dimensions of extraction sockets were measured. The extraction sockets were randomly grafted with DBBM+PRGF or DBBM. The ungrafted extraction sockets were allowed to be filled with clot which served as control. The dogs were sacrificed after 3 months and the extraction sockets were evaluated from clinical and histological viewpoints. Results. There were significant differences in post extraction vertical dimensions of the sockets among the study groups. The mean AC changes were 6.25±2.13 mm, 6.83±1.83 mm, and 3.83±1.63 mm in DBBM, BDDM+PRGF, and control groups, respectively (P=0.034). The mean BL dimension reduction in both DBBM+PRGF and DBBM groups was 2.00±1.09 mm, whereas this amount was 2.66±1.47 mm in the control group (P=0.627). The greatest amount of bone resorption occurred in the control group whereas the PRGF group exhibited the least amount of bone resorption. The control group exhibited a complete bone fill and bone formation rate which was more than that in the experimental groups. Conclusion. The findings of this study indicate that using of DBBM with and without PRGF might successfully maintain socket dimensions.

The present study was envisaged to compare the efficacy of adjunctive use of Azithromycin with scaling and root planing (SRP) the adjunctive use Amoxicillin and SRP, and SRP alone in the treatment of chronic periodontitis. To correlate the use of N-Benzoyl DL-Arginine 2- Naphthylamide (BANA) hydrolysis test and percentage of spirochete count with the periodontal parameters before and after periodontal therapy. Thirty subjects with chronic periodontitis were randomly selected and divided into three groups as follows. Group I: Subjects treated with scaling and root planing (SRP) alone. Group II: Subjects treated with SRP and systemic administration of Amoxicillin (SRP + AMOX). Group III: Subjects treated with SRP and systemic administration of Azithromycin (SRP + AZM). Periodontal parameters comprising of plaque index, bleeding index, probing pocket depth, clinical attachment level and microbiological parameters comprising of spirochete count and BANA test scores were assessed at base line and six weeks after completion of periodontal therapy for subjects in all the three groups. The reduction in post-treatment scores as compared to pre-treatment scores of plaque index, bleeding index, pocket depth, clinical attachment levels and spirochete count was highly significant in all the groups.

Background and aims. The aim of the present study was to assess the hypothesis that an osteopenic diathesis may accelerate or exaggerate periodontal disease via evaluation of the clinical association between systemic bone mineral density and periodontal disease. Materials and methods. The subjects included 150 patients (mean age ≥ 45 years old) who were referred for evaluation of bone mineral density. After measurement of body mass index, skeletal bone mineral density (BMD) was assessed by Dual energy X-ray Absorptiometry (DXA) at femur and lumbar spines. Seventy five patients with lower than normal BMD values (49: Osteopenic, 26: Osteoporotic) were allocated into the case group and the rest of the subjects with normal BMD were allocated into the control group. Periodontal examination involved clinical probing depth (CPD), clinical attachment level (CAL), bleeding on probing (BOP), tooth mobility and the number of remaining teeth. The data were analyzed using chi-square test and student’s t-test. Results. There was no significant difference with respect to CPD, BOP, the number of remaining teeth, and tooth mobility between case and control groups. However, clinical attachment loss in subjects of the case group was significantly higher than the control group. Conclusion. Although it was not possible to demonstrate a causal relationship between bone mineral density and clinical attachment loss in the periodontium, it appears that these two parameters are strongly correlated.

Background and aims. This study was undertaken to evaluate efficiency of patient files in the Periodontics and Oral Medicine Departments to determine the quality of the therapeutic services offered. Materials and methods. The dental files of patients referring to the above-mentioned departments at Tehran Faculty of Dentistry were evaluated. There were 600 and 4000 files in the Periodontics and Oral Medicine Departments, respectively. Of the 4000 files in the Oral Medicine Department 400 files were randomly selected by a masked dental student. Four checklists were used for data collection, which were specific for each department, consisting of the topics covered in the files. Descriptive statistical tests were used for data analysis using SPSS software. Results. The files in the Department of Oral Medicine had the highest mean of filled items, which is attributed to the limited number of items in the files. In the Oral Medicine Department no relation was found between student gender and the quality of files; however, the year of entry into the university was significantly related to the quality of the files. There was a significant relationship between gender and the year of entry into the university on one hand and the quality of files on the other. In the Periodontics Department half of the follow cases had been signed and confirmed by the instructors. Conclusions. The results showed patient files are not sufficiently efficacious in the departments under study and the academic staff need to revise educational methods and remove unnecessary items from the curricula.

Background and aims. Periodontal disease is a complex interaction between bacteria and susceptible host. MMPs has a key role in periodontal disease and increase with disease severity which cause destruction of extra cellular matrix in chronic periodontitis. HMT is a therapeutic hypothesis which its objection is the reduction of tissue destrucion. Doxycyclines can inhibit MMPs activation through the synthesis of intracellular enzymes. The objective of this study was to evaluate the Effectiveness of adjunctive Subantimicrobial Dose Doxycycline on phase I of periodontal therapy. Materials and methods. Forty patients with chronic periodontitis were included in this randomized double blind placebo control parallel group clinical study. After scaling and root planning patients were randomly assigned to two groups, receiving either SDD or placebo bid for 3 months and were evaluate in 3month and 6 month later. Results. Clinical parameter improved significantly in both groups (p-value˂0.0001). Significant reduction in PD, CAL and BOP was seen in SRP +SDD group compare to control group (p-value˂0.0001). Conclusion. Short administration of SDD gives significant benefit in clinical parameters in chronic periodontitis.

Background and aims. Gingivitis is a common periodontal disease which involves different parts of gingiva to various degrees and severity. Unsaturated fatty acids have the potential to decrease the inflammation and can be effective in treatment of gingivitis. The aim of this study was to evaluate the effect of omega-3 unsaturated fatty acids in treatment of moderate gingivitis. Materials and methods. This evaluation is a double blind clinical trial which was performed on 50 patients, 20 to 40 years old, with moderate gingivitis. Patient with same oral hygiene were assessed during 28 days and divided in to two groups. The test group received omega3 unsaturated fatty acids and the control group got the placebo for 10 days. Gingival Index (GI; Loe & Silness) and bleeding On Probing (BOP; Barnet) were recorded on the ramfjord teeth in the day of the prescription and the 5, 10 and 20 days after that. Data were analyzed by Friedman and Man-Whitney statistical tests. Results. The indices showed decrease in both groups significantly.

Placement of the dental implant has become a popular option for oral rehabilitation in edentulous patients. The inter-foraminal area of the anterior mandible has become the elective area for the placement of implants. This area is also prone to vascular accidents because of the rich vascular anastomoses that supply this area. We present a case of slight perforation of one of the implants during surgery which just missed the sublingual branch. It was followed for a period of one year and no relevant complications were seen.

In the article "Relationship between preeclampsia and periodontal disease" by Ardeshir Lafzi, Amir Eskandari, Nader Abolfazli, Ehsan Khashabi, and Sara Golmohammadi, which appeared in J Periodontol Implant Dent 2011;3(2):79-82, the fifth author's name is misspelled. It should be Shima Golmohammadi. The journal regrets this error.