فهرست مطالب

Iranian Journal of Blood and Cancer
Volume:6 Issue: 1, Autumn 2013

  • تاریخ انتشار: 1392/09/25
  • تعداد عناوین: 9
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  • Einollahi N., Alizadeh Sh, Dashti N. *, Nabatchian Fa, Zare Bovani M., Abbasi S., Mohamadian M., Kashani Khatib Z. Pages 3-9
    Background
    Serum lipids abnormalities have been observed in various forms of cancers including acute leukemia. Investigators report decreased total cholesterol and HDL, and elevated triglyceride in leukemic patients. Limited studies had been performed to discover the correlation between abnormal lipids profile and disease activity in leukemic patients in Iran. This study was done to evaluate the levels of serum lipid in Iranian leukemic patients, before and after chemotherapy. Patients and
    Methods
    Seventy eight recently diagnosed and non-treated patients with acute leukemia were included in our study. Blood specimens were collected without anticoagulant before and after chemotherapy; serum was separated and total cholesterol, serum triglyceride, high density lipoprotein cholesterol and low density lipoprotein cholesterol were assessed by enzymatic kits. Statistical analysis was performed using SPSS16.0.
    Results
    The mean age of patients was 24.87 years (range 9-52), with newly diagnosed ALL in 48 patients and AML in 30 patients. From the participating patients 42(53.8%) were male and 36(46.2%) were female. Data analysis showed that the mean total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol, in all age groups and in both sexes, were significantly lower before chemotherapy than after; whereas, mean triglyceride was higher before therapy than after.
    Conclusion
    Based on our findings, it seems that lipid profile assessment can be employed as beneficial prognostic factor in acute leukemia. Besides, it can be a simple, fast and economical method to follow up the patients’ response to chemotherapy. Key words: Acute Leukemia, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglyceride.
    Keywords: Acute Leukemia, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglyceride
  • Miri M., Tabrizi Namini M., Hadipour Dehshal M. *, Sadeghian Varnosfaderani F., Ahmadvand A., Yousefi Darestani S., Manshadi M. Pages 11-17
    Background
    Iran is one of the countries located on “the thalassemia belt” with a significant annual number of thalassemia new births. Given the importance of thalassemia prevention, a program to this effect was approved in Iran in 1995. Screening of carrier couples and prenatal diagnosis were the two main elements of this program. In the present study, the authors have tried to address the impacts of prevention efforts in Iran (1989-2009) and also the status of new birth cases of thalassemia during the time period ranging from 1989 when the Iranian Thalassemia Society was established to 1995 when the prevention program started to run.
    Materials And Method
    The data were obtained from the countrywide haemovigilance network. The data were then compared against the available information in the thalassemia treatment network of Iran and some other thalassemia associations. The available information had been collected through questionnaires and in some cases by phone calls and emails.
    Results
    The findings show that the average thalassemia carrier prevalence rate in the country is about 4% and the thalassemia prevention in Iran has been successful with the number of new born thalassemic patients falling from 1087 cases in 1989 to 239 in 2009. The success rate of the program was evaluated to be 82.3% in 2009.
    Conclusion
    The results show that the thalassemia prevention program has played an effective role in lowering thalassemia births in Iran. Nonetheless, the still high number of new thalassemia cases in the year 2009 is worth considering Keywords: Prevention of thalassemia, Iran, thalassemia, thalassemia carrier rate, success rate, screening, prenatal diagnosis.
    Keywords: Prevention of thalassemia, Iran, thalassemia, thalassemia carrier rate, success rate, screening, prenatal diagnosis
  • Hashem Boroojerdi M. *, Daneshvar N., Ghoraishizadeh P., Ramasamy R., Seman Z., Noor S. Pages 19-26
    Background
    Myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. Understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. Patients and
    Methods
    We compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome and 30 patients with idiopathic thrombocytopenic purpura as the control to perform a quantitative analysis of the antigen expression patterns in granulocytic, monocytic, erythroid and lymphoid lineages and myeloid precursors.
    Results
    Quantitative analysis of CD markers, showed that the mean percentages of CD33, CD13, CD11b, HLA-DR, CD10 and CD34 positive granulocytes were 91%, 84.98%, 77.20%, 14.59%, 40.34% and 34.25%, respectively in myelodysplastic syndrome and 96.89%, 91.57%, 81.47%, 10.56%, 58.30% and 32.37%, respectively in idiopathic thrombocytopenic purpura. Flow cytometric analysis of erythroid lineage showed the mean percentage of CD71 in myelodysplastic syndrome and idiopathic thrombocytopenic purpura cases to be 64.54% and 83%, respectively. Investigation of antigen expression in the myeloid precursors of myelodysplastic syndrome patients showed the mean proportions of: 19.89%, 59.53%, 57.26%, 69.24%, 60.64% and 23.43% for CD117, CD34, HLA-DR, CD33, CD13 and CD11b, respectively. Also, idiopathic thrombocytopenic purpura cases showed the mean percentages of 11.73%, 45.67%, 58.90%, 74.28%, 70.16% and 15.66% for CD117, CD34, HLA-DR, CD33, CD13 and CD11b, respectively.
    Conclusion
    There is no doubt that providing the reference values for an antigen expression pattern among myelodysplastic syndrome cases enhances the utility of flow cytometric analysis interpretation among these patients. Keywords: Myelodysplastic syndromes, flow cytometry, immunophenotyping, antigen expression.
    Keywords: Myelodysplastic syndromes, flow cytometry, immunophenotyping, antigen expression
  • Davoudi, Kiakalayeh A. *, Faranoush M., Haghbin A., Behboudi F. Pages 27-31
    Background
    To evaluate the present status of blood utilization and develop practice guidelines in teaching hospitals in Northern Iran.
    Methods
    We retrospectively analyzed the amount of blood prepared and used preoperatively for 11 elective procedures, from March 2010 to March 2011 in teaching hospitals in Northern Iran. Study variables included the crossmatch transfusion ratio, the transfusion index and transfusion probability. The crossmatch transfusion ratio and the transfusion index were also calculated for each type of elective surgery performed during the study period.
    Results
    During the study period, 5981 units of blood were crossmatched for 1970 cases. Out of these1835 units of blood were transfused which means only 31% of blood was utilized while 69% was not needed. The overall crossmatch transfusion ratio for 11 procedures was 31.1 and many procedures were found to have a high transfusion ratio and a low transfusion index.
    Conclusion
    The introduction of maximum surgical blood-order schedule will lead to a reduction of blood outdating and crossmatch workload. Although routine cross match seems necessary for two elective surgical procedures (coronary artery bypass graft and hysterectomy); in vast majority of elective surgical procedures type and antibody screening is recommended. Keywords: Blood, transfusion, crossmatch, ratio, probability, index.
    Keywords: Blood, transfusion, crossmatch, ratio, probability, index
  • Zangooei R., Vakili M., Hedayatiasl Aa, Azizzade F., Rahbar M., Faranoush M Pages 33-39
    Background
    Population based research contributes to our understanding of cancer at many levels. For health program planning and policy making it is important to have information about the incidence of the common cancers in the population. Descriptive epidemiologic studies measure the occurrence of cancer and other health-related factors in relation to person (e.g. age, sex, race, social class, and behavioral factors), place, and time. The aim of the present study was to present the demographics of common cancers in a referral hospital in Tehran the capital city of Iran. Patients and
    Methods
    In a cross sectional study existing files of patients with diagnosis of cancer in our center in a 13 years period were reviewed. Evaluation of the age, sex, primary site, histology, stage of disease and treatment were recorded. The results were analyzed using SPSS software version 11.5 and depicted in tables and graphs.
    Results
    One thousand and two patients with cancer (esophagus, gastric, colon, breast, lung, and lymphoma) aged 11 to 110 years at diagnosis were assessed. The Male/Female ratio was 509/493. Common cancers in the male population were esophagus, stomach, colon, and lung cancers and in the female population were breast, esophagus, gastric and colon cancers. The most common cancer in this center was esophageal cancer. Cancer was more common in females below the age 60 years and in males after the age 60. In our hospital patients were often admitted with advanced stage of the disease.
    Conclusion
    Increasing the public knowledge and awareness about cancers, importance of early diagnosis, available therapeutic modalities and high cure rate will help to improve survival of cancer in developing countries. Key Words: Epidemiology, prognosis, incidence, survival, cancer.
    Keywords: Epidemiology, prognosis, incidence, survival, cancer
  • Keikhaei B. *, Hirad Far A., Abolghasemi H., Mousakhani H., Ghanavat M., Moghadam M., Falsafi, Zadeh S., Karimi Z., Ghasem Zadeh A., Dorali Nabi N Pages 41-46
    Background
    Transfusion is the mainstay treatment of patients with thalassemia major and occasionally in thalassemia intermediate. Alloimmunization is an unwanted side effect of blood transfusion. The present study intended to determine the frequency of alloimmunization in patients with β- thalassemia major and thalassemia intermediate in Southwest Iran. Patients and
    Methods
    This was a cross-sectional study on 133 transfusion dependent β-thalassemia patients at Shafa hospital-in Southwest Iran. The method of antibody screening was the tube method. All panel test phases were done at immunohematology laboratory of Iranian Blood Transfusion Organization.
    Results
    There were 66 males (49.1%) and 67 females (50.9%) with the mean age of 17.5 years (SD±7.5) included in this study. The antibody screening panel test was positive in 42 patients (32.06%). Twenty five patients (18.7%) had alloantibody and 17 patients (12.7%) also had autoantibody. The predominant pattern of alloimmunization was alloantibodies against RH sub groups system in 55 percent of patients and 33% of patients had alloantibodies against Kell system. Three important factors that significantly influenced the frequency of alloimmunization were: age at the first blood transfusion, splenectomy and β- thalassemia intermediate.
    Conclusion
    Alloimmunization is a common complication among patients with transfusion dependent β-thalassemia in Khuzestan province, Iran. Matching the selected donors with recipients based on the extended red blood cell antigen typing may decrease the incidence of alloimmunization. Key Words: Alloimmunization, thalassemia major, thalassemia intermediate, RH blood group, Kell blood group.
    Keywords: Alloimmunization, thalassemia major, thalassemia intermediate, RH blood group, Kell blood group
  • Vahidfar M., Hossein Abdolahi A. Pages 47-49
    Background
    To investigate the frequency of different types of gynecological tumors among patients who were operated in Shahid Sadoughi hospital, Yazd, Iran, for 3 years.
    Material And Methods
    This study investigated 101 patients with gynecological tumors from March 21.2008 to March 20 2011.. Lesions were considered in 5 groups according to the prevalence of malignancy. Lymph node and peritoneal involvement were also investigated.
    Results
    The mean age±SD at diagnosis was 50.54±12 years. The most prevalent pathologies were serous, musinous, endometrioid and undifferentiated.
    Conclusion
    The age group 40-60 years was the most prevalent among other age groups. Endometrioid tumor was the most prevalent kind of malignancy and undifferentiated was reported as the least prevalent.
    Keywords: Ovarian neoplasms, epidemiology, age, pathology, Iran
  • Alavi S. *, Kaji Yazdi M., Arzanian Mt Pages 51-53
    FMS-like tyrosine kinase-3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is important for the normal development of stem cells and the immune system. Mutations of FMS-like tyrosine kinase-3 have been detected in about 30% of patients with acute myelogenous leukemia and a small number of patients with acute lymphoblastic leukemia. The FMS-like tyrosine kinase-3 mutations most often involve small tandem duplications of amino acids within the juxtamembrane domain of the receptor and are called internal tandem duplications. The other type of mutations in FMS-like tyrosine kinase-3 is located in the activation loop of the second tyrosine kinase domain. Multiple studies have shown that activating mutations of FMS-like tyrosine kinase-3 are common in blasts from patients with AML but are rarely found in adult patients with acute lymphoblastic leukemia. In addition, activating FLT3 mutations occur only rarely in T-ALL cases. Here we report a 3-year-old girl with ALL who had a mutation in FMS-like tyrosine kinase-3 / internal tandem duplications.
    Keywords: FMS, like tyrosine kinase, 3, mutation, acute lymphoblastic leukemia, childhood
  • Goudarzi Pour K. *, Eshghi P., Aghakhani R., Askari Reza A., Nejat Mahmud P Pages 55-57
    Neuroblastoma is a common tumor in pediatric cancer and which might present with usual or unusual clinical features. One of the rare clinical finding of neuroblastoma is paraneoplastic syndromes. We report a two year-old girl with presentation of bilateral ptosis and abdominal pain which was diagnosed as having neuroblastoma. Our case is a very rare case of neuroblastoma accompanied by bilateral ptosis as a paraneoplastic syndrome.
    Keywords: Neuroblastoma, paraneoplastic syndrome, bilateral, ptosis