فهرست مطالب

Iranian Journal of Pediatric Hematology and Oncology
Volume:4 Issue: 1, Winter 2014

  • تاریخ انتشار: 1392/12/22
  • تعداد عناوین: 8
|
  • Tavasolian F., Abdollahi E., Vakili M., Amini A Pages 1-4
    Acute lymphoblastic leukemia (ALL) constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. ALL affects both children and adults. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms. The aim of this study was to investigate the association between ALL and ABO blood group.
    Material And Method
    This is a case-control study that was carried out in Amir Oncology Hospital in Shiraz during 2011 to2013. The case group consisted of 293 patients with acute lymphoblastic leukemia. And compared with 300 subject in control group (the age in the case group was between 2-5 year, and the age in the control group was between 2-45 year). Statistical analyzes was done performed by chi –square test. The results was considered significant when p value <0.05. (CI:0.95)
    Results
    The ABO blood group distribution was 82(A), 59 (B), 24 (AB) and 128(O) in patient with Acute Lymphoblastic Leukemia and the blood group of 300 participants in the control group include, 63% (25) A, 69% (25.6) B, 18 % 06.8) AB and 101% (42.6) O. The ABO blood group distribution showed that there is significant differences between ABO blood group and patients with acute lymphoblastic leukemia.
    Conclusion
    This study showed significant association between ALL and ABO blood group and showed that blood group AB was associated with a higher risk of All (p value<0.001).
    Keywords: Acute lymphoblastic leukemia, ABO blood group, Children
  • Banihashem A., Ghasemi A., Ghaemi N., Moazzen N., Amirabadi A Pages 5-10
    Background
    The most common malignancy of children is Leukemia, accounting approximately one third of cancer diagnosis. Available data demonstrate improvement in survival of pediatric leukemia, so evaluation of side effects of treatment is very important. This study investigates hyperglycemia and diabetes mellitus prevalence in pediatric patients with acute leukemia.
    Materials And Methods
    This study was performed in children with acute leukemia. At the first admission, demographic data was collected and blood glucose and HbA1c levels were obtained. These tests examined at least two times during six months of follow up. Growth parameters and blood samples were obtained too.
    Result
    Twenty nine patients were examined; three of them (10.3%) had diabetes mellitus and 5patients (17.2%) had transient hyperglycemia.Mean age of the patients was 6.26 years and nineteen Children (63%) were in preschool age. In preschool age children, incidence of hyperglycemia was meaningfully higher than school age children (p= 0.02). 24 of 29 patients (82.7%) were known case of acute lymphoblastic leukemia (ALL) and 5 patients (17.3%) were known case of acute myeloblastic leukemia (AML). No significant difference was found between sex groups. Also underweight was significant risk factor for hyperglycemia.
    Conclusion
    The prevalence of hyperglycemia was in the range of other similar studies in different parts of the world. Underweight and preschool ages were significant predictors of hyperglycemia.
    Keywords: Acute Leukemia, Diabetes Mellitus, Hyperglycemia
  • Bani S., Hassanpour- Siahestalkhi A., Hassanpour Sh, Mommad- Alizadeh- Charandabi S., Mirghafourvand M., Javadzadeh Y Pages 11-16
    Background
    Iron deficiency anemia is a global health problem, and approximately 50% of anemia is caused by iron deficiency. According to studies, iron supplementation in young females improves iron status by increasing concentration of hemoglobin. To compare of prescribing two methods of iron supplementation administered either on a weekly basis or during menstruation, on hemoglobin level and menstrual blood¸ this double blind Randomized clinical trial study was carried out among female students in Tabriz, Iran.
    Materials And Methods
    In this double-blind randomized clinical trial, 150 female students allocated randomly in two groups. (75 students took an iron tablet weekly and 75 students took an iron tablet for first four days during their menstruation cycle for 16 weeks). Before and after intervention, the level of hemoglobin was measured and Higham chart was completed byparticipants in each group. Chi-square, independent t-Test, paired t-Test and ANCOVA were used for data analysis.
    Results
    There was no significant difference between two groups in terms of demographic characteristics, hemoglobin level and amount of menstrual bleeding before and after intervention (p>0.05). Taking iron supplement increased significantly the level of hemoglobin in each group (p<0.001). However, there was no significant difference in amount of menstrual bleeding (p>0.05) when comparing the data before and after intervention in each group.
    Conclusion
    The two iron supplementation methods (menstrual bleeding period and weekly) have similar results on Hemoglobin level and menstrual bleeding.
    Keywords: Hemoglobin, Iron supplement, Menstrual bleeding
  • Eghbali A., Taherahmadi H., Shahbazi M., Bagheri B., Ebrahimi L. Pages 17-21
    Background
    Frequent blood transfusion is often associated with iron overload. Proper use of iron chelators to treat iron overload requires an accurate measurement of iron levels. Magnetic resonance T2-star (T2* MRI) can measure iron level in the heart and liver. Our goal was to see whether an association exists between serum ferritin level and T2* MRI in patients with major beta thalassemia.
    Materials And Methods
    Sixty patients with a diagnosis of major beta thalassemia were enrolled in the study. They were older than five years old and needed regular transfusion. Cardiac and hepatic T2*MRI and mean serum ferritin levels were measured within 3 months.
    Results
    No significant correlation was observed between serum ferritin level and cardiac T2*MRI (p=0.361, r=-0.120).However, a significant correlation was observed between serum ferritin and liver T2*MRI (p=0.021, r=-0.297).
    Conclusion
    Our results showed an association between hepatic T2*MRI and serum ferritin level.
    Keywords: Ferritin, Iron chelator, Major thalassemia, T2*MRI
  • Ebrahim Zadeh A., Bamedi T., Etemadi S., Shahrakipour M., Saryazdipour Kh Pages 22-25
    Background
    Toxoplasma Gondi is an obligate intracellular protozoan parasite that is one of the most important protozoa of blood and tissue. The medical importance of this parasite is considered from two aspects of congenital defects and opportunities among those with congenital immune deficiency. Depending on the mode of transmission through blood and the risk of infection to Toxoplasma Gondi in hemodialysis patients, this serological study was conducted on Iranian population.
    Materials And Methods
    This case-control study was conducted on 37 patients that underwent regular hemodialysis that 21 were male and 16 were female, and the mean age of them was 17.52±4.10 years (rages 13-22 years).Thirty-seven healthy individuals were chosen as control group. All samples were tested by using of ELISA kits with two methods of IgG-ELISA and IgM-ELISA. Finally obtained data was analysis by SPSS software.
    Results
    The results of this study revealed high prevalence of toxoplasmosis among hemodialysis patients. Other findings indicate that 21 out of 37 patients in the case group were positive for anti-Toxoplasma Gondi IgG in case group while in control group just 11 individuals were positive that was a statistically significant difference(p <0.05).
    Conclusion
    because of the high prevalence of toxoplasmosis among hemodialysis patients, identification of these patients for prevention of transfusion complications is important.
    Keywords: ELISA, Hemodialysis, Serology, Toxoplasmosis
  • Manoochehri J., Masoumi Dehshiri R., Faraji H., Mohammadi S., Dastsooz H., Moradi T., Rezaei E., Sadeghi Kh, Fardaei M. Pages 26-31
    Background
    Wilson disease (WD) is a rare autosomal recessive disorder, which leads to copper metabolism, due to mutations in ATP7B gene. The gene responsible for WD consists of 21 exons that span a genomic region of about 80 kb and encodes a copper transporting P-type ATPase (ATP7B), a protein consisting of 1465 amino acids. Identifying mutation in ATP7B gene is important to find carrier individuals for proper counseling. A novel mutation in exon 8 of ATP7B gene, c.2335T>G (p.Trp779Gly), with severe neuropsychiatric condition in the South of Iran, was recently identified. The aim of this study was to screen 120 individuals from a large family using a simple amplification refractory mutation system PCR (ARMS-PCR) for carrier screening in the South of Iran.
    Materials And Methods
    120 individuals from family relatives of an index case in the Nasr Abad, south of Iran, were studied for screening of the c.2335T>G mutation. One patient with homozygous mutation and one homozygous normal individual were used as controls in this experiment.
    Results
    Altogether, 16 out of 120 (13.3%) individuals within this region had heterozygous mutation. One individual with homozygote mutation was also identified.
    Conclusion
    Identification of carriers in families with affected individuals is of great importance for counseling before marriage. The results of this study can be used for further counseling programs in this population.
    Keywords: ARMS, PCR, c.2335T>G, p.Trp779Gly, South of Iran, Wilson disease
  • Azimi F., Jafariyan M., Khatami S., Mortazavi Y., Azad M Pages 32-38
    For the past half century, thiopurines have earned themselves a reputation as effective anti-cancer and immunosuppressive drugs. Thiopurine S-methyltransferase (TPMT) is involved in the metabolism of all thiopurines and is one of the main enzymes that inactivates mercaptopurine. 6-MP is now used as a combination therapies for maintenance therapy of children with acute lymphocytic leukemia (ALL). In all patients receiving mercaptopurine, there is a risk of bone marrow suppression.TPMT activity is inherited as a monogenic, co-dominant trait. More than 25 variants are known. Genetic testing is available for several TPMT variant alleles. Most commonly TPMT*2, *3A, and *3C are tested for, which account for >90% of inactivating alleles. Differences in DNA that alter the expression or function of proteins that are targeted by drugs can contribute significantly to variation in the responses of individuals.Genotyping may become part of routine investigations to help clinicians tailor drug treatment effectively. This success is mainly due to the development of combination therapies and stratification of patients according to risk of treatment failure and relapse, rather than the discovery of new drugs. The aim of this study was to investigate the effect of genotype or methyltransferase enzyme activity before starting therapy in children with ALL. This can prevent the side effect of thiopurine drugs. In fact, the common polymorphism of this enzyme in population could be a prognostic factor in relation to drug use and treatment of patients with ALL.
    Keywords: Acute lymphoblastic leukemia, Azathioprine, 6, Mercaptopurine, 6, Thioguanine, Myelosuppression, Polymorphism
  • Hashemi A., Sheikhha Mh, Manouchehri Ma, Kalantar Sm Pages 39-41
    Background
    Monosomy is defined as the presence of only one chromosome instead of two in humans. Partial monosomy occurs when only a portion of the chromosome is present in a single copy, while the rest has two copies. It can occur in unbalanced translocations or deletions. Case report: In this report, a 6 years old girl was presented who was referred to the Pediatric Dep, Shahid Sadoughi Hospital,Yazd, Iran, due to multiple congenital anomalies such as: frontal bossing, horizontal palpebral fissure, small deepest eyes, aplastic nasal bridge, broad philtrum, low set ears, large prominent ears, short neck, microcephaly, pectus excavatum, mental retardation, and dislocation of the hip.In peripheral blood smear, platelets were decreased but other hematological levels were normal. The karyotype result indicated a mosaic monosomy and partial monosomy of chromosome 21.
    Conclusion
    According to this and other case reports of monosomy of chromosome 21, this disease had very low prevalence rate among live infants or children. The present case had some congenital anomalies that present with abnormal medical condition. Therefore these patients must be evaluated for chromosomal studies.
    Keywords: Congenital anomalies, Chromosome 21, Partial monosomy, Platelets