International Journal of Cancer Management
Volume:7 Issue: 4, Autumn 2014

Cancer is usually accompanied by considerable stress for the sufferer, and the stress has destructive effects on Chemotherapy treatment process. Therefore, the current research deals with the effect of yoga laughter on the cancer patients’ stress before chemotherapy. In this research, as the first step, 37 cancer sufferers, who had been hospitalized in Shohada Tajrish Hospital (Behnam Daneshpoor Charity Organization) and had the requirements necessary for being taken as research samples, were selected for data collection. The mentioned patients were classified randomly in experimental and control groups. Collected data were analyzed by the multi-variable covariance analysis test. The results show there is a meaningful difference in the stress average before and after interference in the test group (p<0.05). Laughter yoga can decrease the stress in cancer sufferers before chemotherapy.

This study is conducted to compare meta-cognition treatment and mindfulness-based stress reduction treatment on life quality of women with breast cancer. in aquasi-experimental design, with pre-test and post-test and controlgroup,36 patients with a diagnosis of breast cancer, among patients who referred to the Division of Oncology and Radiotherapy of Imam Hossein hospital in Tehran, were selected in available way and were assigned randomly to two experimental groups, the first one receiving meta-cognition treatment (n=12)and the second one receiving mindfulness-based stress reduction program(n=12), and one control group. Participants completed global life quality of cancer patient''s questionnaire and specific life quality of patients with breast cancer questionnaire in three stages, baseline, after intervention and two-month follow-up. Data were analyzed by multivariate repeated measurement model. Findings showed both treatments were effective in improving global and specific life quality of patients with breast cancer. Mindfulness -based stress reduction treatment excelled in functions and role, fatigue, pain, future perspective and treatment side effects symptoms at the end of the treatment and follow-up in comparison to meta-cognition treatment. Results of this research showed mindfulness-based stress reduction treatment can be effective in improving global and specific life quality of women with breast cancer and is a selective method for improving life quality of patients. Results of this research showed the mindfulness-based stress reduction treatment can be effective in improving global and specific life quality of women with breast cancer and is a selective method for improving quality of life in patients.

Cancer immunotherapy attempts to stimulate the immune system to reject and destroy tumors and is one of the cancer treatment strategies. Recently, interluekin36 (IL36) has been used as immunotherapeutic agents in cancer gene therapy. Present study investigated that the IL36 gene therapy effects on the regression of tumor masses in mouse model. Aim of this study is determination of the gene therapy effects by IL36 in the regression of tumor masses in mouse model. To study the therapeutic efficacy of this cytokine, WEHI-164 tumor cells were transected with mIL36 plasmids. ELISA test was used to check cytokine production by transected cells. To establish fibro sarcoma mouse model, Tumoral transfected cells were injected subcutaneously to inoculate tumor in BALB/C mice. Tumor volumes were measured by caliper. Mice were sacrificed and tumors were extracted. The expression of IL36 and IFN-γ was studied with Real-time PCR and immunoblotting. The expression of Ki-67 (a tumor proliferation marker) in tumor masses was studied by immunohistochemistry staining. In this study we had 2 groups which are treated with IL-36 and Untreated with IL-36 as a blank. The group treated with IL36 indicated decrease of tumor mass volume (p<0.001). The results of western blotting and real-time PCR showed the IL36 expression increased in the group treated with IL36 (with relative expression of 1.9). Immunohistochemistry staining indicated that the Ki-67expression has been reduced in the group interfered with IL36. IL36 gene therapy has therapeutic effects on the regression of tumor masses in fibro sarcoma mouse model.

Prostate cancer is a serious genetic disease known as the first widespread cancer in men, yet the molecular changes required for the cancer progression is not fully understood. Availability of high-throughput gene expression data has led to the development of various computational methods for the identification of critical genes involved in the cancer.In this paper, we show that constructing co-expression networks using Y-chromosome genes provides an alternative strategy for detection of new candidate may involve in prostate cancer. In our approach, we constructed independent co-expression networks from normal and cancerous stages using an engineering approach. We next highlighted crucial genes involved in the prostate cancer by analyzing networks based on party and date hubs.Our results led to the detection of 19 critical genes related to prostate cancer which 12 of them were previously shown to be involved in this cancer. Also, essential Y chromosome genes were searched based on reconstruction of sub-networks which led to the identification of 4 experimentally established as well as 4 new Y chromosome genes may be linked putatively to prostate cancer.Correct inference of master genes whose mediate molecular changes during cancer progression is one of the major challenges in cancer genomics. In this paper, we show the role of Y chromosome genes in finding of prostate cancer susceptibility genes. Application of our approach to the prostate cancer has led to the establishment of the previous knowledge about this cancer as well as prediction of other new genes.

To prevent and control the cancers in Iran, the Iranian Department of Health has released the cancer rates data of the country. As the report has suggested, the incidence rate of thyroid cancer would be the most rapidly increasing among all the cancers. The study has aimed to carry out a qualitative assessment of thyroid cancer in Iran, during the 2004 to 2009, in a cross-sectional setting. The incidence rates, the trend of individual provinces, the mean age at which the disease occurred, the correlation between incidence rate and median urinary iodine concentration were the parameters evaluated in our study. The average annual incidence rate during these six years was 2.17 per 100000. Chaharmahal-o-bakhtiari, had the highest incidence rate, but the East Azerbaijan provinces had the lowest incidence rates respectively. The age of diagnosis was the lowest in Ardebil but the highest in West Azerbaijan. We have assessed the role of median urinary iodine concentration in the thyroid cancer trend, and have found a positive correlation between them (p-value=0.025). Presently, the only recognized measure procedure for reducing thyroid cancer risk would be perhaps the correction of median urinary iodine concentration. Further researches have seemed to be required for investigation the other factors, in order to introduce preventive measures in Iran.

Primary Gastric Lymphoma (PGL) is an uncommon malignancy with various histological subtypes and treatment outcomes. The aim of this study was to investigate the potential prognostic factors and clinicopathological characteristics of Iranian patients with PGL. The clinicopathological characteristics of 60 patients with PGL were retrospectively reviewed from 2001 to 2012. The patients underwent various combinations of chemotherapy, radiotherapy, and surgery. We evaluated multiple potential prognostic factors and their associations with patient survival rate. According to the results, Diffuse Large B-cell Lymphoma (DLBCL) and Mucosa-Associated Lymphoid Tissue (MALT) were two predominant histological subtypes. The majority of cases were diagnosed with stage I tumor in the distal part of the stomach. The 5-year disease-free survival (DFS) and overall survival (OS) rates were 60% and 70%, respectively. It was revealed that poor World Health Organization (WHO) performance status, presence of B symptoms, and International Prognostic Index (IPI) score≥3 were significantly associated with decreased patient survival. Most of the patients with PGL in early stage have a favorable prognosis.

Although Cervical cancer mortality has reduced during last years, but it is still leading cause of mortality among women. Many efforts have performed to develop new drugs and strategy to cure cervical cancer. Mesenchymal stem cells (MSCs) have many advantages that make them a suitable choice as a cell therapeutic agent in cancer treatment. There are different transfection methods for MSCs transduction that one of them is based on application of lentiviral vector. In this study we aimed to develop an improved protocol for Mouse MSCs transduction as well as assess the homing capacity and incorporation of MSCs in cervical cancer model. MScs were isolated from the mouse adipose tissue and characterized by differentiation and flow cytometry. In our study, lenti vector transductions of MSCs performed by three times inoculation of virus with interval of eight hours. Their penetrations were detected in tissue sections after injection of transduced MSCs to cervical cancer model. The results showed that, MSCs efficiently transduced with lenti vector using our improved protocol and have good penetration in tumor tissue. The results provide evidence that, MSCs were able to penetrate through tumor mass of cervical tumor model and are good vehicle for gene transfer to cervical cancer.

Stage at diagnosis is one of the most important prognostic factors for most of the cancers like breast cancer. Studies have found that the rate of late-stage diagnosis of breast cancer among women with lower socioeconomic status is more than the others. The aim of this study was investigating the relationship between family levels of socioeconomic status and stage at diagnosis of breast cancer. This cross-sectional, descriptive study conducted on 526 patients who were suffering from breast cancer and registered in Cancer Research Center of Shahid Beheshti University of Medical Sciences from March 2008 to December 2013. A reliable and valid questionnaire about family levels of socioeconomic status filled by interviewing the patients via phone. For analyzing the data, Multinomial logistic regression, Kendal tau-b correlation coefficient and Contingency Coefficient tests were executed by SPSS19. The results indicated that the mean age of the patients was 48.30 (S.D. = 11.41). There was a significant relationship between stage at diagnosis of breast cancer and family levels of socioeconomic status at the time of diagnosis (P= 0.024). Also, the relationship between stage at diagnosis and place of living (living in Tehran or not) was significant (P= 0.044). In the Multiple logistic regressions, these associations were significant. There wasn’t any significant relationship between stage of diagnosis of breast cancer and age, marital status and family history. Owing to the results of this study, paying attention to the family socioeconomic status as an important variable in stage at diagnosis of breast cancer among Iranian women is important and presenting preventing plans related to this topic seems necessary.

Paratesticular sarcomas have happened rarely. Due to the infrequency of this malignant disease and its diverse histopathologic subtypes, no standard treatment would be available. Multiple treatments have reported in literature with different results. We have reported a 55 years old man with a 30 years history of paratesticular mass. After multiple operations, radical orchiectomy has revealed liposarcoma. The patient has been receiving 50 Gy radiation to the scrotum and inguinal area. After 18 months follow up, the patient was well and disease free. He has shown good response to surgery and radiotherapy, so we have reported the disease and its clinical course.

Inflammatory pseudotumour describes as a wide range of neoplastic and reactive lesions. One of the rare presentations of these tumors is found in the salpinx. This case report characterizes a thirty six year old woman with a history of left sided abdominal pain for a few months. Further examinations revealed that she had a complex cyst in her left salpinx. The patient had normal levels of tumor markers such as CA125, Alfa Fetoprotein (AFP), and Human Chorionic Gonadotropin (hCG), while other paraclinical test were in normal values Additionaly The patient underwent left salpingectomy by a gynecologist. The pathological diagnosis of the lesion was inflammatory myofibroblastic tumor (IMT). In immunohistochemistry the tumor stains was moderately positive in anaplastic lymphoma kinase (ALK) and also actin positive. Total resection of tumor was performed with no complications and remained disease free during follow up for 40 months. Although Inflammatory Myofibroblastic Tumor (IMT) is benign in nature, but in order to improve the prognosis, this tumor requires low intensity surgical treatment.