مجله دانشکده پزشکی اصفهان
پیاپی 316 (هفته اول اسفند 1393)

Northeastern Iran، particularly Mashhad city، is an endemic area for human T-cell lymphotropic virus type 1 (HTLV-I) infection; although، there is no data available on the prevalence of HTLV-II in this region. This descriptive-analytical study aimed to evaluate the prevalence of HTLV-II using nested polymerase chain reaction (PCR) method in general population of Mashhad.

From general population of Mashhad، 1678 individuals were selected using multistage cluster sampling. Serum samples were tested for the presence of HTLV antibodies using enzyme-linked immunosorbent assay (ELISA) assay. To confirm HTLV-II infection، TAX gene and long terminal repeat (LTR) region were amplified using designed specific primers by nested PCR method.

From 1678 individuals، 1654 serum samples were taken، of which، 56 were positive for HTLV antibodies via ELISA method. All reactive samples were examined by nested PCR for the presence of HTLV-II provirus. None of the cases were positive for HTLV-II infection.

The results of present study demonstrate no evidence of HTLV-II infection in the general population of Mashhad. However، it is recommended to investigate the prevalence of the virus among high-risk groups، specially injecting drug users in this region.

Todays، using of mobile phones has an important role in human life and public concern about the harmful effects of radiation emitted by these devices is growing. In addition، protecting questions and biological effects are among growing concerns that have remained largely unanswered. Stem cells are useful models to assess the effects of radiofrequency electromagnetic fields (RF-EMF) on other cell lines. Adipose tissue represents an abundant and accessible source of adult stem cells. Therefore، this study was performed on adipose-derived stem cells (ADSCs).

ADSCs were exposed to global system mobile communication (GSM) mobile phones 900 MHz with intensity of 354. 6 µW/cm2 waves (217 Hz pulse frequency، 50% duty cycle)، during different exposure times، ranging from 6 to 21 minutes/day for 5 days at 20 cm distance from the antenna. MTT assay [3- (4،5-dimethylthiazol -2-yl) -2،5-diphenyltetrazolium bromide] was used to determine the growth and metabolism of cells and trypan blue test was also done for cell viability. Statistical analyses were carried out using analysis of one-way ANOVA. P < 0. 05 was considered to be statistically significant.

The proliferation rates of human ADSCs in all exposure groups were significantly lower than control groups (P < 0. 05); except in the group of 6 minutes/day that did not have significant difference with control groups.

The results show that 900 MHz radiofrequency signal radiation from antenna can reduce cell viability and proliferation rates of the human ADSCs regarding the duration of exposure.

Acne vulgaris is considered as one of the most common disorders for which، patients seek dermatologic care. In the current study، we evaluated the efficacy of the 5% nicotinamide gel versus 2% clindamycin gel in the treatment of the mild to moderate acne vulgaris.

This randomized، controlled clinical trial was performed in 2009-2010. Sixty female patients with mild or moderate acne vulgaris were recruited to be treated either with 5% nicotinamide or 2% clindamycin gel for 8 weeks. Acne severity index (ASI) was used to evaluate the response to treatment and SPSS software was used to analyze the data.

The mean of ASI at the baseline was 16. 85 ± 8. 50 and 18. 20 ± 12. 27 in nicotinamide and clindamycin groups، respectively (P > 0. 0500). The mean of ASI was significantly decreased compared with baseline during the time in both groups (P < 0. 0001). However، there was not any significant difference regarding reduction of ASI between the nicotinamide and clindamycin groups (P = 0. 5830).

Five percent nicotinamide gel is as effective as 2% clindamycin gel for treatment of mild to moderate acne vulgaris. No side effect was observed during the treatment. Keywords: Acne، Clindamycin، Nicotinamide، Treatment

World Kidney Day (WKD) is a joint initiative of the International Society of Nephrology (ISN) and the International Federation of Kidney Foundations (IFKF). Seven years on from the first campaign، World Kidney Day (WKD) has turned into a global phenomenon. On March 13، 2014، medical professionals، government officials، the general public، celebrities and patients took action locally. In 2014، the World Kidney Day (WKD) focused on chronic kidney disease and aging. The mission of WKD is to raise awareness; so that، everyone cares for their kidneys and، if appropriate، check to assess if they are at risk for kidney disease. Prevention of kidney disease، early detection، and subsequent kidney protection are critical aims for World Kidney Day.