Jentashapir Journal of Cellular and Molecular Biology
Volume:6 Issue: 1, Feb 2015

Pathologic changes may occur in dental follicle of impacted teeth, which makes the microscopic evaluation of enlarged follicle an important issue. One of the exceedingly rare conditions seen in dental follicles is multiple calcifying hyperplastic dental follicles, which has microscopical appearance similar to central odontogenic fibroma (WHO type).. A 13-year-old boy, in the case presented in this article, had 15 unerupted teeth, each associated with hyperplastic pericoronal tissue.. The purpose of this article is to report an example of this entity and describe the histopathologic characteristics that helps diagnose and treat such condition in the most appropriate manner..

Coronary artery disease (CAD) is one of the major causes of death worldwide. There is a direct relationship between increased levels of blood cholesterol, triglycerides (TG), low density lipoproteins (LDL), high density lipoproteins (HDL), nitric oxide (NO), and high sensitivity C-reactive protein (hs-CRP) and the CAD. Walnut may reduce these factors and consequently decrease the risk of CAD.. The aim of this study was to evaluate the effect of walnut consumption on TG, LDL, cholesterol, HDL, NO, and hs-CRP in patients with CAD and healthy people..Patients and In this randomized crossover clinical trial, 70 patients with CAD were divided into two groups: case and control groups. The patients were given 40 g walnuts daily for 4 weeks. After 4 weeks, the TG, LDL, cholesterol, HDL, NO and hs-CRP levels were measured. The experiment was also carried out on healthy people (3 groups) with normal range of lipid. The LDL, HDL, cholesterol, and hs-CRP levels were measured using commercially available kits. The nitric oxide level was measured using the Griess reaction method.. The cholesterol and LDL levels decreased significantly from 202.43 to 187.46 and 123.80 to 108.63 mmol/L (7.9% and 13.9 %), respectively in healthy subjects after the treatment (P < 0.01). In the experimental group, there was no significant difference in cholesterol (P = 0.110) and LDL levels (P = 0.176) before and after the treatment. Moreover, no significant difference was observed in other parameters between the two groups.. The walnut consumption did not affect cholesterol levels in patients with CAD; however, it might be administered as an agent for reducing the cholesterol, which is one of the risk factors associated with CAD..

Mothers of children with attention deficit hyperactivity disorder (ADHD) may have distinctive parenting attitudes and mental health problems.. This study examined the parenting attitudes, general health, and some other related factors in mothers of children with ADHD.. Sixty mothers of children with ADHD who referred to psychiatric outpatient clinic of Ahvaz Golestan Hospital were selected by convenience sampling method. The parenting attitude, general health, and demographic data questionnaires were used.. Forty two (70%) mothers were healthy and 18 (30%) were unhealthy. The Pierson coefficient and the Fisher’s exact test showed only a significant relationship in maternal age with the total score of general health questionnaire (GHQ) (r = -0.350, P = 0.05) and the score of anxiety subscale (r = -0.429, P = 0.05). The scores of different attitudes were 29.45 ± 5.71 for dominating, 29.13 ± 6.08 for ignoring, and 27.8 ± 5.8 for possessive attitudes. Mothers with elementary school education level had fewer possessive attitude than higher educated mothers (P = 0.017). The ignoring attitude was significantly higher in staff members than others (P = 0.043). Logistic regression model also showed that the GHQ score was significantly related to maternal age (P = 0.027) and number of children (P = 0.011).. Dominating, ignoring and possessive attitudes are frequent in mothers of children with ADHD. Parenting attitudes in mothers of children with ADHD may have relationships with job and education level. Mothers of children with ADHD, especially in younger ages and more offsprings may be predisposed to mental health problems, especially to anxiety..

Recently, researchers evaluate disorders of the lumbo-pelvic region such as low back pain through assessment of movement patterns with various clinical tests. Prone knee-flexion is one of the most common tests, which are used.. The purpose of this study was to investigate the changes in lumbar lordosis during the prone knee-flexion test in healthy subjects..Patients and This quasi-experimental study with repeated measurements was performed on 40 healthy subjects. Lumbar lordosis was measured with a standard flexible ruler first in prone position and then, after performing the prone knee-flexion test. The amount of change in lumber lordosis between the two measurements was recorded. Data were analyzed using paired t-test.. Results demonstrated that there was a statistically significant difference in lumbar lordosis in prone position and after performing the prone knee-flexion test among healthy subjects (P < 0.0001).. An increased lumbar lordosis during the prone knee-flexion test is due to instability in a lumbar spine region..

This study was conducted to examine the efficacy of honey and vitamin E on fertilization capacity of noise-exposed rats by assessing whether the plasma sexual hormones levels i.e. follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone are altered in relation with noise stress.. Therefore, this study aimed to evaluate the effects of honey and vitamin E on the levels of sex hormones and male fertilization capacity of noise-exposed rats.. This study targeted 24 male rats that were randomly divided into four equal groups including the control group that were not exposed to noise and experimental groups 1, 2 and 3 that were the untreated, honey treated and vitamin E treated groups, respectively; all of which were exposed to noise for 50 days. Next, in order to measure serum sexual hormones, blood samples of experimental and control groups were taken and analyzed. Also in order to investigate the fertility capacity of rats, the male rats of all groups were coupled with female rats.. The results showed that in the male rats exposed to the noise stress, the levels of FSH and LH rose and the testosterone secretion fell sharply compared to not exposed rats. Additionally, the continuing effects of noise stress injury could reduce the weight of the fetus and the number of live fetuses and survival rate of the fetus. However, honey and vitamin E improved serum testosterone concentration, while declined plasma FSH and LH secretion in noise-exposed rats and enhanced fertility rate by increasing the rate of healthy alive fetuses.. It seems that noise pollution has harmful effects on the fertility of males. Also these findings may suggest the use of a natural curative approach rather than pharmaceutical drugs to optimize both neuroendocrine gonadal axis and testicular integrity induced by pathogenesis stress, and enhance fertility capacity in men..

Polycystic ovary syndrome (PCOS) is the most common cause of oligoovulation and anovulation in general population and in females with infertility.. The purpose of this study was to compare the efficacy of ovarian laparoscopic drilling procedure (LOD) in females with PCOS, resistant to treatment with estradiol (E2) level less than 40 pg/mL versus more than 40 pg/mL.. Females with PCOS, resistant to drug for ovary stimulation, were grouped based on the Estradiol levels of ≤ 40 pg/mL (n = 13) and > 40 pg/mL (n = 15). To survey the ovulation, continuing spontaneous ovulation and cumulative pregnancy rate, ovarian laparoscopic drilling was carried out after the analysis of serum E2.. There was significant difference in the average starting time of ovulation and continuing spontaneous ovulation of cases with PCOS with E2 levels > 40 pg/mL, compared with ones with E2 ≤ 40 pg/mL (P = 0.029, P = 0.05, respectively). Significant differences were also found in pregnancy rates of cases with PCOS with E2 levels > 40 pg/mL compared with ones with E2 ≤ 40 pg/mL (P = 0.05).. This study revealed that LOD in females with PCOS with a serum E2 > 40 pg/mL was sufficient and safe to trigger development of ovarian follicles followed by clinical pregnancy..

Acute Fatty Liver of Pregnancy (AFLP) is one of the serious complications of the pregnancy period. Surveying the laboratory and clinical signs is effective in timely prognosis and fast treatment of this illness.. The current study aimed to evaluate AFLP among the hospitalized subjects..Patients and This retrospective study was conducted on clinical and preclinical records of 25 females with AFLP for maternal and perinatal prognosis from 2000 to 2009. The data was analyzed using SPSS ver. 19.. The patients aged 16 - 45 years old with one to four pregnancies (pregnancy); they were 24 to 39 weeks pregnant with the mean of 33.56 weeks, and 56% were multifarious. The most prevalent clinical symptoms were nausea, vomiting, abdominal pain, headache, pruritus, and icterus. The laboratory signs included disorders of liver, coagulation, kidney, and hypoglycemia. Nausea and vomiting in the first and second age groups (Group 1, patients were < 25 years; Group 2, patients were 25 - 35 years) and abdominal pain (100%) in the third group (Group 3, patients were > 35 years.) were the most prevalent symptoms. No patient had fever, ascites, and polydipsia. There was one case of mother and fetal death.. In the current study, the clinical and paraclinical signs of AFLP were mostly - liver, coagulation, kidney, and hypoglycemia disorders. Considering that patients mostly refer in three phases of clinical, laboratory, and complications, it is essential to evaluate the suspected ones who present clinical symptoms especially nausea, vomiting and abdominal pain..

According to the definition by the National Institutes of Health of USA, a biological marker (biomarker) is a characteristic that is objectively measured and evaluated, as an indicator of normal biological processes, pathogenic processes or pharmacological responses, to a therapeutic agent. Several studies have reported that a decreased regulating gene expression of biotinidase (BTD) is associated with breast cancer. On the basis of these evidences, we hypothesize that in the serum of breast cancer patients, with different pathological grades, reductions in serum BTD enzyme activities, there are significant differences. The use of this marker, as a diagnostic and prognostic marker for breast cancer, is a promising perspective for the clinical field..