مجله دانشگاه علوم پزشکی شهید صدوقی یزد
سال بیست و سوم شماره 3 (پیاپی 104، خرداد 1394)

Ptosis is the vertical narrowing of the palpebral aperture secondary to drooping upper eyelid. Due to the various types of ptosis and its complicated nature، selecting the appropriate surgery is extremely important. Therefore، this study aimed to compare the results and complications of ptosis surgery in children and adult groups in Yazd Shahid Sadoughi Hospital. In this retrospective study، profile of 212 patients were examined in two groups of less than 15 years old and more than 15 who had undergone corrective surgery for ptosis between 2000 and 2010 in Shahid Sadoughi hospital. Demographic data، the involved eye (right or left)، familial history (FH)، ptosis type and mechanism، surgical technique as well as the results and complications of surgery were documented via a questionnaire، and the study data was analyzed using SPSS (version 18). In total، 212 patients were studied in two age groups (<15 years: 47. 2% female، 52. 8% male and >15 years: 53. 8% female، 46. 2% male). Positive FH and congenital ptosis were reported significantly more frequent in the first group (<15years). Levator resection (LR) method was done in 67% of cases in both groups and sling fontalis (SF) was performed in 28. 3% and 22. 6% in each group respectively. The normal eyelid position، under correction and over correction were reported 76. 5%، 2. 8% and 20. 7% respectively in first group and 56. 6%، 11. 3% and 32. 1% in the second group. The success rate of SF was higher than LR. As a matter of fact، the difference was statistically significant in both groups، whereas no significant difference was observed in regard with the surgery complication between the two groups. The study findings revealed that the success rate of SF was more than LR in all patients and ptosis corrective surgery results were reported to be better in <15 years group.

Preoperative anxiety is known as a complaint in the majority of patients referring to surgery. Considering the effect of some medicinal plants as anti anxiety and sedative, this study was conducted to compare the effectiveness of Citrus Aurantium and oxazepam tablets on anxiety before coronary artery bypass graft.

In this clinical trial, 66 patients, aged 40-65, were selected and randomly divided into two groups, who underwent coronary artery bypass graft surgery in Namazee and Shahid Faghihi Hospitals. Patients in group A (33 patients) received 10 ml (equivalent to 2 mg) of Citrus Aurantium per day for three days before surgery, and patients in group B (33 patients) took a tablet of Oxazepam (10 mg) in a single dose orally, the night before the operation. The patients’ anxiety was measured by Spielberger Anxiety Inventory. Moreover, the study data was analyzed by using t-test and paired t-test in SPSS software.

The study results revealed that anxiety in Citrus Aurantium group decreased significantly (P=0.00) after the intervention, whereas in oxazepam group, although anxiety levels decreased, the difference was not reported to be significant (P=0.29). In comparing anxiety level changes between the two groups, the difference was not observed to be significant (P=0.23).

The results obtained from the present study indicated both Citrus Aurantium and Oxazepam tablets have similar effects on anxiety. Therefore, Citrus Aurantium can be used as an effective drug to reduce anxiety in patients before surgery.

Defects in PTEN gene play an important role in the initiation of the prostate cancer. MAGI2 is recognized as a frame which assists in stabilizing PTEN protein and enhances its tumor suppressor function. As miR-101 down-regulates MAGI2 expression, it can indirectly cause to reduce the PTEN activity. LnCap, PC3 and DU-145 prostate cancer cell lines were studied in order to investigate expression ofPTEN,MAGI2and miR-101 using TaqMan probe Real-time PCR assay. The relative expression of each gene was determined based on their CT value and CT method. The study results demonstrated that miR-101 and MAGI2 expression was down-regulated in all the three cell lines in comparison to prostate cancer tissue. However, despite the high expression of miR-101 in prostate cancer tissue, MAGI2 expression was not significantly affected in this sample. The expression of PTEN gene in LnCap and PC3 cells was significantly lower than its expression in DU-145 cells. This can be explained by the complete loss of the PTEN gene at DNA level. The findings of the present study confirmed the loss of the expression of PTEN and MAGI2 genes in PC3 and LnCap cells, which may be due to MAGI2gene rearrangements in a mutually exclusive manner.

Peganum harmala from the zigophilauses family has compounds such as: alkaloid, saponine steroid and lignin which in used as a traditional medicine with antibacterial, anti-tumor, inhibition of MOA enzyme, and stimulation of the nerves system. Therefore, the aim of the present study was to evaluate the effect of the methanolic extract of Peganum harmala on serum levels of thyroids hormones parameters of adult rats. In this experimental study, conducted at Academic Center for Education, Culture and Research (ACECR) of Qom in 2012, 60 adult female rats weighed approximately 200±10 grams were divided into 4 groups: the control group, and 3 experimental groups (100,200,400 mg/kg Peganum harmala oral extract daily for 60 days). Finally by collecting the blood samples of the animals, serum level of TSH, T3 and T4 were measured and the collected data were analyzed via SPSS software utilizing ANOVA. The study results revealed that the 200, 400 mg/kg Peganum harmala extract significantly reduced the TSH, T3, T4 levels in rats, whereas experimental group of 100 mg/kg extract Peganum harmala did not demonstrate any significant changes. The study results indicated that the Peganum harmala extract might be used for treatment of hyperthyroidism and its related complications. However further studies are necessitated to explore this concept.

The routine use of drains in uncomplicated laparoscopic cholecystectomy(LC) has still been controversial. Therefore, this study aimed to investigate the advantages and disadvantages of applying drains in uncomplicated LC. This study is a randomized prospective interventional study without blindness. After removing gallbladder, 60 patients were randomized to have corrugated drain positioned in the subhepatic space and 60 patients were randomized to have no drain. Patients were assessed for abdominal pain, nausea, vomiting, and the length of hospital stay 24 hr after the surgery. Then, they were assessed for biloma two weeks after the surgery. No significant difference was observed in regard with nausea, vomiting and biloma in either group. However, abdominal pain (p-value: 0.001) and the length of hospital stay (p-value: Conclusion