فهرست مطالب

Colorectal Research - Volume:3 Issue: 2, Jun 2015

Iranian Journal of Colorectal Research
Volume:3 Issue: 2, Jun 2015

  • تاریخ انتشار: 1394/06/15
  • تعداد عناوین: 7
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  • Shahryar Zeighami, Seyed Ali Eslahi *, Mohammad Mehdi Hosseini, Ali Ariafar, Sara Pakbaz, Mohsen Rastegari, Hajar Khazraei Page 1
    Introduction
    Extramedullary hematopoiesis (EMH) commonly occurs in the spleen, liver and lymph nodes. Rare cases of EMH in the adrenal gland have been reported..
    Case Presentation
    We report the case of a 33-year-old man from the South of Iran suffering from major β-thalassemia, who underwent open left adrenalectomy and the histopathology revealed EMH..
    Conclusions
    In patients in which a history of hematologic disorders exists, careful imaging and hormonal assay should be done to certify a diagnosis of EMH. However, the surgical management becomes inevitable in certain cases..
    Keywords: Extramedullary hematopoiesis, Thalassemia, Adrenal
  • Seyed Vahid Hosseini, Alimohamamad Bananzadeh * Page 3
  • Bahareh Fakhraei, Ali Firouzabadi, Mojtaba Farjam, Mohammad Reza Fattahi, Mohammad Hasan Kazemi, Mahvash Alizade Naini, Maryam Moini * Page 4
    Background
    Functional gastrointestinal (GI) disorders are very common and many patients with such disorders are not satisfied with treatment outcomes. Psychological aspects of functional disorders need special attention that may play an important role in patient management..
    Objectives
    In this study, psychology evaluation was performed for a population of patients with functional bowel disorders..Patients and
    Methods
    One hundred patients with functional bowel disorders including 50 patients with irritable bowel syndrome (IBS) referred to GI clinics were candidates for psychiatry evaluation; of those 60 patients completed the study. Psychiatric disorders were diagnosed using a structured clinical interview based on diagnostic and statistical manual of mental disorders IV (DSM IV)..
    Results
    Of 60 patients with functional bowel disorders (including 39 IBS), 51 (85%) were diagnosed with at least one psychiatry disorder. The most common disorders were dysthymia (25%) and obsessive-compulsive disorder (20%). There was no significant difference between IBS patients and other functional bowel disorders regarding the prevalence of psychiatric disorders..
    Conclusions
    Psychiatric disorders are very prevalent among patients with functional bowel disorders. Prompt diagnosis and appropriate management of associated psychiatric disorders along with GI targeted treatments may lead to a better outcome in these patients..
    Keywords: Functional Gastrointestinal Disorders, Mental Disorders, Irritable Bowel Syndrome
  • Peter Edward Coyne *, Reza Kalbassi Page 5
    Context: Intra-abdominal sepsis has significant morbidity and mortality. In the developed world, there are many common causes originating from the lower gastrointestinal tract including diverticular disease, appendicitis, perforated cancers, and inflammatory bowel disease. It has a high cost and is associated with high levels of significant morbidity and mortality. Management options include radiologic drainage and surgical options include resection for more widespread sepsis. Laparoscopic surgery has increased and has been useful in elective setting. Its use in the emergency setting is less evaluated..Evidence Acquisition: Evidence was acquired by searching online medical databases including Pubmed, Medline and Embase..
    Results
    Laparoscopic surgery has been shown to have a role in the acute setting. Studies show it has become the gold standard in the appendicitis. High quality Randomized controlled trials are in short supply but observational and cohort studies have shown equivalence and with increasing experience complication rates are reduced. Evidence is also increasing in the management of diverticular disease, crohn’s and ulcerative colitis as well as post-operative complication management and acute presentations of colorectal cancer..
    Conclusions
    Laparoscopic surgery is feasible in the management of intra-abdominal sepsis. It has become the new accepted standard in the management of appendicitis, and is safe, feasible and increasing in the management of complex diverticular disease, acute IBD and colorectal cancer in the emergency and post-operative setting..
    Keywords: Diverticulitis, Appendicitis, Laparoscopy, Crohn's Disease, Colorectal Cancer, Ulcerative Colitis
  • Ali Reza Safarpour, Fatemeh Kaviyani, Masood Sepehrimanesh *, Nasrollah Ahmadi, Omid Koohi Hosseinabadi, Nader Tanideh, Najmeh Showraki Page 6
    Background
    Ulcerative colitis (UC) is a chronic condition of intestine illness accompanied by some unknown etiology with different immune, genetic and environmental factors..
    Objectives
    The current study aimed to evaluate the antioxidant and anti-inflammatory effects of the Melilotus officinalis L. in the acetic acid induced UC in rats..
    Materials And Methods
    The plant aqueous extraction and high performance liquid chromatography and Ferric Reducing Antioxidant Power (FRAP) assay were performed on aqueous extract to identify its compounds and antioxidant activities. Also, 70 adult male rats were and UC was induced using 3% acetic acid solution. They received different daily doses of M. officinalis L. in two forms (orally, 500 and 1000 mg/kg) and gel extract (10% and 20%). On the 7th day, the colon tissues were examined regarding the macroscopic and histopathology lesions plus oxidative stress and compared to the positive and negative control groups..
    Results
    HPLC analysis revealed that five grams of the flower powder contained 9.7 mg gallic acid, 99 mg catechin, 21.9 mg caffeic acid, 0.86 mg chlorogenic acid, 1.13 mg quercetin, 548.9 mg cinnamic acid, 289 mg coumarin and 126 mg p-coumaric acid. The FRAP value of the extract was 2.91 ± 0.14 μM/g. There were significant differences between the group of rats which received the gel or aqueous extract of the flower compared to the negative control group using normal saline and the base gel and they had no significant differences with the positive control group using the Asacol, regarding the pathologic, malondialdehyde, and weight improvements..
    Conclusions
    It can be concluded that the M. officinalis L. extract can be used as an effective medicine to treat UC in animal model and also in human subjects..
    Keywords: Colitis, Ulcerative, Inflammation, Extract, Ulcerative Colitis, Asacol
  • Ehsan Solati, Ghodratollah Maddah, Abbas Abdollahi *, Alireza Tavassoli, Masoumeh Safaei, Mehdi Jabbari Nooghabi Page 7
    Background
    Today, with improvements in laparoscopy technique, surgery of rectal cancer is performed by laparoscopy..
    Objectives
    This study was performed to evaluate oncologic results of open versus laparoscopic surgery of rectal cancer in terms of resection margins, removal of lymph nodes and recurrence rate..Patients and
    Methods
    This descriptive-analytic study was performed on 88 patients with middle and lower rectal cancer in the two equivalent groups of laparoscopic and open surgery in Mashhad Ghaem and Omid hospitals during 2011 - 2013. Information including age, sex, number of removed and involved lymph nodes, proximal, distal, and radial margins, tumor stage and location, recurrence and disease-free survival collected in the questionnaire and analyzed using descriptive statistics and frequency distribution tables and t-test..
    Results
    Both groups of open and laparoscopic surgery had similar characteristics of age, sex, recurrence and disease-free survival, tumor margins and one-year mortality. The number of removed and involved lymph nodes was higher in the laparoscopic group (5.16 vs. 3.55, respectively, with P < 0.050, and 1.74 vs. 0.59 with P = 0.023), but the ratio of involved lymph nodes to the total number of removed lymph nodes was not different between the two groups (LNR) (P = 0.071). Tumor stage was higher in the laparoscopic group and most were in stages II and III (P < 0.001)..
    Conclusions
    Laparoscopic surgery is an effective technique for safe margin and removing lymph nodes in rectal cancer..
    Keywords: Rectal Neoplasms, Open Surgery, Laparoscopy