جستجوی مقالات مرتبط با کلیدواژه « Malva Neglecta » در نشریات گروه « پزشکی »

Herbal mouthwashes can improve the oral mucosal wound healing process. Therefore, this study aimed to compare the effect of aqueous extracts of Malva sylvestris and Malva neglecta leaf with common mouthwashes on the oral mucosal wound healing process.

In this Lab trial, an incision was made into the buccal mucosa of 36 Wistar rats using a surgical blade to a depth of superficial fascia and length of 5 mm. Then, 0.2% chlorhexidine mouthwash, 10% Malva neglecta, 10% Malva sylvestris, and normal saline were used for rinsing the rats' mouths three times a day in four experimental groups. On the 4th, 7th, and 10th days, three rats from each study group were randomly selected. Incisional biopsies were made and evaluated using an optical microscope regarding the number of inflammatory cells, fibroblasts, collagen density, and the wound healing process. The collected data was analyzed in SPSS software (version 19) using ANOVA and Tukey post hoc tests.

Groups treated with M. sylvestris and M. neglecta showed the best statistical, clinical, and microscopic healing results with lower inflammatory cells, and more fibroblasts and collagen density compared to other groups (P<0.001).

Based on the results of this study, M. sylvestris and M. neglecta extracts can be used in mouthwashes to accelerate the healing process of oral wounds.

Stroke is the second leading cause of death in the world and has irreversible consequences. Cerebral ischemia/reperfusion (I/R) through production of oxidants and inflammatory markers causes apoptosis of brain neurons. On the other hand, in various studies, the antioxidant and anti-inflammatory effects of the Malva neglecta have been proven. Therefore, in this study, we investigated the protective effect of hydroalcoholic extract of Malva neglecta leaf on pyramidal neurons in the CA1 region of the hippocampus of male Wistar rats following ischemia-reperfusion.

In this experimental study, we divided 24 Wistar rats weighting 350-300 gr randomly into four groups (n=6) as control, Ischemia/reperfusion (I/R), I/R+ hydroalcoholic extract of Malva neglecta leaf was injected intraperitoneally (300 &600 mg/kg 0-24-48-72 hour after the ischemia). The ischemic model was performed by clamping the bilateral common carotid arteries (BCCA) for 20 minutes to induce ischemic injury. After 4 days all groups were sacrificed and brain sections were stained by Nissl and evaluated by light microscope. P<0.05 was assumed as statistically significant.

The results showed that ischemia / reperfusion in the brain for 20 minutes caused degeneration of pyramidal cells in the CA1 region of the hippocampus and the ischemia group showed a significant decrease (P <0.05) compared to the control group. Malva neglecta injection at a dose of 600 mg / kg largely preserved the neurons and was not significantly different from the control group (P = 0.107).

The use of hydroalcoholic extract of Malva neglecta leaf at a dose of 600 mg / kg prevents the reduction and death of neurons in the CA1 region of the hippocampus following ischemia-reperfusion in the brain of Wistar rat. Malva neglecta extract can be used as an effective agent in preventing or reducing the complications of stroke alone or with other drugs.

Gums are polysaccharide components with high molecular weight that easily suspend in water and are dispersed under suitable conditions. They are used as stabilizer, texture modifier, gelling agent, thickener and emulsifier. The aim of this study was to determine the properties of the new Malva leaf’s gum.
The gum was isolated from the leaf of Malva neglecta plant by warm-water extraction. Purification was carried out by barium complexion. Purified gum was evaluated in terms of physicochemical properties. Furthermore, rheological properties of extracted gum were evaluated in shear rate at the range of 0.1–1000 s-1 with Brookfield viscometer and flow behavior and effect of temperature and gum concentration on the viscosity was evaluated.
The Purified gum contained 8.12±0.43% moisture, 77.04± 0.83% carbohydrate, 8.56± 0.62% protein, 2.49± 0.3% ash and 5.33± 0.29% uronic acid. Among the rheological models, power law model appropriately described the behavior of the gum. Arrhenius model was also properly applied to evaluate and describe the relation between gum viscosity and temperature. Three model's power, exponential and polynomial were used to evaluate the effect of gum concentration on the apparent viscosity in the shear rate of 10 s-1.
According to shear thinning behavior, Malva gum can be used in food industry. Extracted gum showed higher sensitivity to temperature at higher levels of gum concentration and power law model was selected as the best model to assess the effect of gum concentration on the viscosity.

Panirak is an annual or perennial herb from the family Malvaceae. In Iranian traditional medicine (ITM), it is mentioned by entry of Khobbazi. Other names mentioned for it in ITM are Malukhia, Malukhie and Malukie. It has cold and moist temperament and is laxative, diuretic, opener of constrictions, and galactogogue. Its seed due to high content of mucilage is appropriate for dry cough, hoarseness and peptic ulcer. Evaluations demonstrate that Panirak is similar to Khobbazi barri saghir and the mentioned botanical descriptions for it in traditional medicine literatures is corresponding to two Malva species including Malva sylvestris L. with Persian name of “Panirak Pa boland” and Malva neglecta Wallr. with Persian name of “Panirak Ravandeh”.

Nanotechnology is an interesting research area due to production of nanoparticles of different sizes, shapes, chemical compositions, dispersity, and their numerous applications for human being. Creation, manipulation, and use of metallic nanoparticles is of great importance due to reduction of dimensions, and thus having unique thermal, optical, and electronic characteristics. The biosynthesis methods of nanoparticles are prioritized compared to chemical and physical procedures because of lower energy and time costs. Green synthesis of nanoparticles is an eco-friendly method, in which natural solvents are used. In this study, the phytosynthesis of silver nanoparticles by Malva neglecta, was investigated.
The extract of Malva neglecta was used as a reducing agent for biosynthesis of silver nanoparticles. By adding silver nitrate in concentration of 20mM to the extract, the reaction was done at room temperature, that the color change of the extract from pale yellow to dark brown showed the generation of silver nanoparticles.
In this study, the formation of silver nanoparticles was confirmed (by the presence of an absorption peak at 450 nm) using a spectrophotometer. The size and morphology of silver nanoparticles were determined using scanning electron microscopy. The shape of particles was spherical and their average size was about 20nm.
The results of this research showed that silver nanoparticles can be produced by an eco-friendly biological method and without using any harmful chemicals.

Prostodin is a chemical drug، which is often used for pregnancy termination. In traditional medicine، Malva neglecta is used for abortion. In this study، the effects of hydroalcohlic extract of Malva neglecta and prostodin on the liver tissue of female rats were investigated and compared. In this research، 24 female rats were randomly divided into 4 groups of 6 each as follows: The first group was considered as control، which received normal diet (food and water); the second group received extract of Malva neglecta (at a dose of 200mg/kg. bw); the third group received extract of Malva neglecta (500mg/kg. bw) orally; and the fourth group received prostodin (2mg/kg. bw) via intraperitoneal injection. After 18 days of treatment، the rats were anesthetized and their liver was removed for biochemical analysis after cupping. The prepared tissue sections were studied using light microscopy after H&E staining. Data were analyzed by one-way ANOVA and Tukey’s test. The significance level was considered p<0. 05. The serum levels of ALT، AST، LDL، triglyceride، and cholesterol significantly decreased (p<0. 05) in the groups received Malva neglecta and significantly increased in the group received prostodin، compared to the control group. Liver necrosis was observed in liver tissue sections from the group treated with prostodin، but no liver necrosis was observed in the groups treated with Malva neglecta. According to the findings of this study، extract of Malva neglecta، in contrast to prostodin، has protective effect and prevents hepatic necrosis without serious damage to the liver.