XML The Effect of 8-week Aerobic and Concurrent (aerobic- resistance) Exercise Training on Serum IL-6 Levels and Insulin Resistance in Type 2 Diabetic Patients

Introductoin: Increased level of serum IL-6 is related to development of type 2 diabetes and insulin resistance. The American Diabetes Association and the American College of Sports Medicine recommend that combination of resistance and aerobic exercise is favorable for patients with type 2 diabetes. The purpose of this study was to investigate the effect of 8 weeks of aerobic exercise and concurrent (aerobic-resistance) exercise on serum IL-6 Levels and insulin resistance in Type 2 Diabetic patients.

In this study، from patients referring to Kermanshah Diabetes Association، 24 volunteers participated in the study as subjects and were divided into aerobic (n=8)، concurrent (n=8)، and control group (n=8) randomly. Training program for the aerobic group included 3 sessions of running per week with 60 to 80% maximal heart rate for 8 weeks but the concurrent group in addition to running، performed resistance training of major muscles groups. Before and after the intervention، body weight، BMI، fasting blood glucose، serum IL-6 and HOMA-IR were measured.

HOMA-IR and fasting blood glucose were significantly decreased in both training groups after intervention، but showed no significant changes in the control group. No significant changes were observed for serum IL-6 levels، body weight or BMI.

performing 8 weeks of aerobic or concurrent training with improvement of insulin resistance and fasting blood glucose could be helpful for type 2 diabetic patients; however، it cannot significantly affect serum IL-6 levels، body weight، or BMI in these patients.