Study of Some Teratogenic Effects of Gabapentin Drug on NMRI Mice Embryo

The aim of study was designed to determine the created macroscopic abnormalities by Gabapentin during of implantation and organogenesis of fetus. In this experimental study forty female mice (NMRI type) were used. Female pregnant mice were divided in four groups (each one 10) consist of three experimental groups (I، II، III) and one control (received normal saline). Three experimental groups received 15، 30 and 45 mg/kg/day of Gabapentin respectively by intraperitoneally (ip) injection from day 6. 5 (GD6. 5) to day 14. 5 (GD14. 5) of pregnancy. Animals were dissected in 18. 5 day of pregnancy and their embryos were studied using stereomicroscope from the macroscopical abnormalities. Embryos weight and length were measured and recoded based on CR length. Data were analyzed by T-test، Tukey test and ANOVA using SPSS software. In all three experimental groups (I، II، III) was observed a significant reduction in comparison with control in body weight and CR length (P<0. 001). Also significant increasing was observed in abnormalities appearance such as fetal absorption، organs bleeding and follicular thyroid in comparison with control. Gabapentin drug is caused fetal absorption، weight and CR length reduction in mice embryo during organogenesis. Also it induces some abnormalities such as hemorrhage and follicular thyroid in embryonic period.