Stimulus Induced Signal Improvement in 6-Hydroxydopamine Model of Hemi-Parkinsonian in Rat

Parkinson's disease is a degenerative disorder of the central nervous system. Parkinson’s symptoms are mainly motor related symptoms movement. Deep brain stimulation (DBS) has been considered as a last resort in severe cases of the disease. Our objective was to improve the stimulus signal for DBS in a controlled manner. In current experiment, Parkinson’s model in rats was implemented using 6-hydroxydopamine. Some feedback was needed to improve the parameters of DBS signals. We used electrocardiogram (ECoG) signal feedback. The stimulation and recording were synchronized so it was able to adjust the condition at the real time. In each process the β band energy of recorded ECoG was studied and the best option for next stimulation settings was selected. Quasi-statistic stimulation signal showed better result than normal signal. Significant improvement for the stimulus signal parameters was reached. The present method of DBS could be considered as a therapeutic method and could be examined in larger studies in future.