the comparison of endurance training with endurance training and overtraining on Th1/Th2 balance in wistar male rat

Immune system has role in inflammatory and anti inflammatory function. Base of theses activities is produce IL4 and IFNγ. This study is about effects of endurance training with endurance training and overtraining on balance this two cytokines.
this study 30 rats selected and divided to 3 groups(10) control, endurance and overtraining exercise. Endurance training protocol and overtraining were done for 12 weeks.endurance training done with speed 30 m/min in first week and 23m/min in last week. overtraining protocol was done with speed 15 m/min in first week and 25 m/min in last week. Speleenectomy where done after interval training protocol, and Eliza method used to, Interleukin 4 (IL4) and Interferon γ (IFNγ).
based on this study rsult showed a increase significant in the amount of (IFNγ) and decrease in the levels of IL4 in endurance training group (p=0.01). The results also showed increase in levels of IL4 and decrease IFNγ levels in overtraining group that this difference was significant (p=0.01) .
Based on the results of this research, it can be concluded that doing moderate training lead to increase IFNγ and overtraining case to increase IL4.