Nano- and microfibrous electrospun scaffolds for vascular regeneration

There is an increasing demand for tissue engineered vascular grafts (TEVGs) with long-term effectiveness in order to replace or bypass the diseased vessels. Ideal TEVGs should be biocompatible, blood-compatible and have resistance against aneurysm dilation as well as being easily implantable in body. Tissue engineering field provides an opportunity for designing and fabrication of ideal synthetic grafts, and so far, researchers have studies several materials and methods for this aim. For example, some TEVGs have been made from decellularized natural tissues, biopolymers and biodegradable synthetic polymers. However, the researchers still encounter with some challenges including true mimicking the mechanical properties of natural tissues and enough neo-tissue ingrowth. Electrospinning is a conventional techniques that has a great potential to solve these problems. In this paper, the performed studies on fabrication of electrospun vascular scaffolds have been reviewed.
The English abstract is translate of the Persian one. But, unfortunately, it has not 150 words, while the Persian abstract has 180 words.