Adipolin and Insulin Resistance Response to Two Types of Exercise Training in Type 2 Diabetic Male Rats

Adipolin (CTRP12), which improves insulin sensitivity, is a novel anti-inflammatory adipocytokine secreted from adipose tissue. In this study we aimed to assess the Adipolin and Insulin Resistance index (HOMA-IR) response to two types of exercise in type 2 diabetic male rats.
In this study, 24 diabetic Wistar rats (Induced by high-fat diet and Streptozotocin(stz) injection) were randomly assigned to 3 groups: High intensity interval exercise (HIIT), low intensity continuous training (LICT) and control (C). Both training groups were trained on the treadmill, 5 sessions per week for 8 weeks. Blood samples were taken 24 hours after the end of training session and plasma adipolin, insulin and glucose levels were measured. ANOVA and Tukey post hoc tests were used to analyze data and the level of significance was considered to be p≤0.05.
Data analysis showed that plasma adipolin levels in the low intensity continuous training group were significantly increased, compared to the control group (p=0.006). Plasma glucose level in both the low intensity continuous training and the high intensity interval groups was significantly decreased, compared to the control group (p=0.049) & (p=0.007). Plasma insulin level in both training groups was increased and HOMA-IR index was decreased, compared to the control group, although changes were not significant.
The results of this study showed that exercise training can increase plasma adipolin in rats with type 2 diabetes, changes however that are partially dependent on the type of exercise training.