Protective Effect of Soy on Movement Disorders Induced by Parkinson Disease in Ovariectomized Animal Model

Investigations have shown that ovarian steroids are involved in reduction of movement disorders during neurodegenerative diseases especially Parkinson's disease. These steroids have many side effects, thus, other estrogenic agents with fewer side effects are needed to develop alternative treatment strategies. The main objection of this study was to evaluate the effects of soy meal on movement disorders in ovariectomized animal model of Parkinson's disease.
Animals were divided into 3 groups: intact, treated by normal diet and treated by soy meal diet. Female Wistar rats with the exception of intact group were ovariectomized at the first line of study. Then Stride length test was done and animals received special diet for 4 weeks post substantia nigra pars compacta (SNc) electrical lesion. At the end, Stride length and Morpurgo's test was performed.
Soy meal diet in ovariectomized rats with SNc Lesion improved muscle stiffness without any effect on stride length.
Our results suggest that soy meal is a potential alternative to estrogen in the treatment of Parkinson’s disease.