Effect of Deacetyl chitin on VEGF Gene Expression in Metastatic Breast Cancer Model
Author(s):
Abstract:
Background and
Purpose
Breast cancer is one of the leading causes of death in women around the world. Conventional treatments use cytotoxic drugs which have high levels of side effects. Today, researchers are more interested in developing novel drugs that have lower side effects and maximum efficiency. Deacetylchitin is a biodegradable and biocompatible polymer. The goal of this research was to evaluate the effect of Deacetylchitin on VEGF gene expression in metastatic breast cancer model.Materials And Methods
In this study, Deacetyl chitin nanoparticle was synthesized. The size and zeta potential of nanoparticle was determined. Mouse models of breast cancer were treated by Deacetyl chitin. Expression of VEGF genes was evaluated using real time PCR.Results
Deacetyl chitin nanoparticle size was 210 nm. Statistical analysis showed that Deacetyl chitin reduced the expression of VEGF gene (PConclusion
Deacetyl chitin reduced the expression of metastatic genes on mouse models of breast cancer, therefore, it could be suggested as a new tool for future therapeutic strategies aimed in cancer therapy.Keywords:
Language:
Persian
Published:
Journal of Mazandaran University of Medical Sciences, Volume:27 Issue: 152, 2017
Pages:
1 to 11
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