Numerical Simulation of Bisphosphonates Effect on Bone Remodeling Around Dental Implants

Nowadays, the use of dental implants in people with osteoporosis is increasing. The consequences of osteoporosis can be important to the success of osteosynthesis devices, prosthetics and dental implants. Using bisphosphonates, which with impressing bone remodeling and decreasing bone catabolic activity lead to increase bone formation can be used as a solution to increase bone density in patients with osteoporosis, which normally osteoporosis is considered as a risk to the acceptance of dental implants by alveolar bone. This study examines the effect of different concentrations of bisphosphonates on bone remodeling. By improving bone remodeling model and taking into account the drug concentration effect on bone resorption, drug effect will be considered. For this purpose, 5, 10 and 20 mg of alendronate per implant and control sample are simulated for a period of 360 days. By comparing the results with control sample, with increasing the drug dose, decrease in bone stress, increase in bone density and thus increase in young's modulus was observed.