Quantitative and qualitative scintigraphic Measurement of normal Wistar rat kidney exposed to saffron administration

Using the modern techniques is really necessary in accurate diagnosis of kidneys abnormalities in these days. This study was done to determine function of the kidneys after saffron administration by using dynamic scintigraphy.
In this study six White Rat underwent dynamic scintigraphic examination by gamma camera and 99mTc- DTPA was used as radio pharmaceutical. Peak activity percentage, time to peak activity (Tmax), Emptying half time (T 1/2), 3 min activity, total and
individual GFR are the parameters that were determined before and after saffron administration separately. We followed the shape of the time activity curves (TACs) for analyzing the function of kidney.
Peak activity percentage, Emptying half time (T 1/2), T max , 3 min activity, Total and individual GFR in left and right kidneys were determined as follow : Peak activity percentage : left 51.83±0.095, Right 48.5±1.17, T 1/2 : left3.43±2.26, Right2.61±1.15, T max : left2.68±0.29, Right1.95±0.05, Total GFR :173.46±11.77
In this study blood flow increasing effect was shown by increasing GFR and decreasing Emptying half time (T 1/2 ).