Dietary Pattern Interactions with Polymorphisms of CCND2, ZNT8 and MC4R Genes, in Relation to Risk of Metabolic Syndrome and its Components

Few studies have investigated the interaction of food patterns with polymorphisms of the MC4R, ZNT8, and CCND2 genes. This study was performed to evaluate the interaction between MC4R rs12970134, ZNT8 rs13266634 and CCND2 rs11063069, polymorphisms and dietary patterns, in relation to MetS. Materials and
A total of 1630 subjects were selected from participants of the Tehran Lipid and Glucose Study. The cases and controls were matched by age, gender and the years of follow-up. Dietary intakes were obtained using a valid and reliable semi-quantitative food frequency questionnaire. Dietary patterns were determined using factor analysis on 25 food groups. MC4R rs12970134 and ZNT8 rs13266634 polymorphisms were genotyped by Tetra-Primer ARMS-PCR Analysis, and CCND2 rs11063069 by the ARMS-PCR Analysis.
The mean ages were 43.3±11 and 43.03±12 years in cases and controls, respectively. Two healthy and western dietary patterns were identified. MetS risk increased in the fourth quartile of western dietary pattern scores, in A allele carriers of rs12970134 (OR: 1.71 (1.04-2.41), compared to other genotypes. This risk decreased in the fourth quartile of healthy dietary pattern scores in G allele carriers of rs11063069 (OR: 0.88(0.39-1.78), P trend According to the results of this study, adherence to healthy or western food patterns could respectively alter the effects of 12970134rs and 11063069rs polymorphisms, on the development of metabolic syndrome.