The Effect of Hydro-alcoholic Extracts of Anethum graveolens L. (Dill) on Amygdala Kindled in Rats

Although hydro-alcoholic extracts of Anethum graveolens L. had Anticonvulsants effect on PTZ-induced kindling seizure behavior, but on the amygdala kindling in rats induced seizure has not been investigated. In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolens L. on seizures using electrical amygdala kindling model. Rats were divided into six groups. They were kindled by stimulating the amygdala by consecutive daily. Then, treated by hydro-alcoholic extracts of Anethum graveolens L. (i.p. 100, 200 and 400 mg/kg) and Afterdischarge Duration (ADD), Stage 4 latency (S4L) and Stage 5 duration (S5D) were recorded. Hydro-alcoholic extracts of Anethum graveolens L. (200 and 400 mg/kg) significantly increased stage 4 latency compare to the control group (P <0.05). Hydro-alcoholic extracts of Anethum graveolens L. (400 mg/kg) injection stage 5 duration caused by amygdala electrical kindling. Hydro-alcoholic extracts of Anethum graveolens L. (100, 200 and 400 mg/kg) injection significantly reduced ADD induced by amygdala kindling. The data showed that injection of hydro-alcoholic extracts of Anethum graveolens L. has anti-epileptic effect and increases the time required for amygdala kindling and may have anticonvulsant effects.