Effects of High Intensity Interval Training (HIIT) On CTRP1 and CTRP3 in Women with Type 2 Diabetes

Family members of C1q/tumor necrosis factor (TNF) related proteins (CTRPs) have been shown to play an important role in metabolism and inflammation. However, there is limited information on the association of high-intensity intermittent exercise (HIIT) with CTRP1 and CTRP3 protein levels in patients with type 2 diabetes. Therefore, this study aims to evaluate the effects of 12 weeks HIIT on CTRP1 and CTRP3 protein levels in women with type 2 diabetes.

In a quasi-experimental study and pretest and post-test design, 30 women with type 2 diabetes (mean±SD, age: 40.69±4.21 years and body mass index:34.81±2.88 kg/m2 ) were randomly into two HIIT group (n=10) and control group (n=15). Exercise group performed a HIIT program three sessions per week, with and intensity of 80-90% MHR, 60 minutes per session for twele weeks. Weight, BMI, Vo2peak, FBG and serum levels of CTRP1 and CTRP3 were measured before and after the study period. The data were analyzed using paired sample t test and analysis of ANCOVA at the level of less than 0.05.

After 12 weeks HIIT, there was significant differences in weight, BMI, Vo2peak, FBG and CTRP3 and CTRP5 serum levels between groups (p >0.05). However, ANCOVA test showed a significant decrease in weight, BMI, FBG and CTRP1 and CTRP3 serum levels and a significant increase in Vo2peak in the HIIT group compared to the control group after intervention (P<0.05).

The findings suggest that 12 weeks of HIIT program were an effective and safe method of improving the CTRP1 and CTRP3 serum levels in obese women with type 2 diabetes. However, more research with more control are needed to determine the effects of this non-pharmacological intervention on anti-inflammatory adipokine.