The effects of local Gazangebine ointment on wound healing in rabbits

Background and Management of cutaneous wounds is an important subject in medicine. Different chemical agents have been used for wound healing but each of them has side effects. In this study, we examined the effects of an experimental ointment derived from a natural product on wound healing. Twenty-four white rabbits divided into three groups as fallows: control, Eucerin and Gazangebine. The ointment was made by Gazangebine extract (9%) and Eucerin in the laboratory. A full thickness wound (2cm ´2cm) was made on the left flank of the test animals. The ointment was applied to the wound area twice daily without any covering as an open wound. Wound area was measured every 3 days until day 18. In this day, rabbits were biopsied to look for histopathological changes. Gazangebine ointment had no beneficial effects on wound contraction. However, it decreased inflammation and neutrophil number (P<0.05, p=0.001) and increased eosinophil number and dermal tissue healing (p<0.05, p=0.000). The results suggest that Gazangebine ointment has positive effects on wound healing.