The Effect of 4 Weeks Resistance Training on Serum Vaspin, Il-6, CRP and TNF-Α Concentrations in Diabetic Rats

Vaspin is a novel adipokine that potentially improves insulin sensitivity. However, there is limited information available regarding the effect of exercise training on serum vaspin concentrations. The purpose of this study was to investigate the effect of resistance training on serum vaspin levels and some inflammatory markers in diabetic status. Thirty six male Wister rats (288±22 g) were randomly divided into four groups: Non-diabetic control, non-diabetic trained, diabetic control and diabetic trained. The exercise groups were subjected to a resistance training program with the use of a ladder (3 days/wk, for 4 wk). Body weight, serum vaspin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF)-α and fasting glucose were measured. Four weeks resistance exercise training in non-diabetic rats decreased serum vaspin levels significantly, while in the trained diabetic group, serum vaspin levels increased significantly when compared with the diabetic sedentary group. The resistance training programme did not however change TNF-α, IL-6 and glucose concentrations. A decrease in CRP was observed in both the resistance trained groups when compared with their control groups. We found that resistance training exercise programmes affected the serum vaspin response of diabetic and non-diabetic groups of rats differently. However further research is warranted in order to unravel the molecular mechanism for the range of responses and the role of serum vaspin. Decreased levels of CRP may also be indicative of the possible effect of resistance training to modulate pro-inflammatory parameters linked to diabetes.