Effects of forced exercise on withdrawal syndrome, brain hippocampal neural count and serum corticosterone hormone level in morphine addicted male rats.

Running title: Forced exercise improves behavioral and brain electrical functions in morphine addicted rat. Morphine addiction causes impairing the behavioral and cognitive performances, reduction of brain neurons and change the hormonal secretion and neurotransmitters release. Aim of the present study was evaluation the effects of forced exercise on treadmill on withdrawal signs after morphine deprivation, serum corticostrone level, and hippocampal neuronal count in brain hemisphers in animals addicted to morphine. Adult male Wistar rats were tested into five groups with 10 in each: 1) exercised control (C+E), 2) sham exercised control (C+Sh.E), 3) addicted (A), 4) exercised addicted (A+E), and 5) sham-exercised addicted (A+Sh.E). Withdrawal signs were counted during 30 minutes after naloxone administration as number of