Benzocoumarin Backbone Is a Multifunctional and Affordable Scaffold with a Vast Scope of Biological Activities

Coumarins having an aryl phenol linked to the 3,4-, 5,6-, 6,7-, or 7,8-binding sites are referred to as benzocoumarins. Efforts have been made in recent years to separate new configurations of benzocoumarin analogues with notable biological activities and to devise novel production procedures to create such agents with unique or even improved bioactivities. The separation and characterization of natural benzocoumarin compounds are briefly described in the first section of this study. The innovative synthetic approaches for the production of benzocoumarin-related compounds and also the documented total pathways to synthesize naturally occurring benzocoumarin derivatives are presented in the second portion. The third part contains a comprehensive summary of the attempts conducted to investigate the pharmacological activities of benzocoumarin related compounds, as well as the additional make-up, methods of production, and bioactivity assessment of therapeutically appropriate analogues. The authors’ aim is to provide an overview of benzocoumarins, including their natural sources, chemical synthetic methodologies, and bio-medicinal activities that have been investigated over the last few decades.