a.h. rezayan

Sepsis is one of the leading causes of death in intensive care units (ICU) and is becoming more prevalent globally. As a result, an accurate and timely diagnosis of sepsis is critical for selecting the best treatment to prevent disease progression and mortality. In this study, CRP and TNF-α as common biomarkers of sepsis were detected using a label-free optical biosensor based on interferometric Fourier transform spectroscopy from a porous silicon substrate. The porous silicon layer was chemically modified with APTES and glutaraldehyde to immobilize the aptamer covalently in order to capture the analyte. The refractive index of the porous layer was determined by analyzing the reflection spectrum from the porous layer, which was associated with different biomarker concentrations. The results demonstrated linear responses in concentrations ranging from 10-10000 ng/ml for CRP and 100-10000 ng/ml for TNF-α and the biosensor's high discrimination. Thus, it has a high potential for advancement in clinical sepsis diagnosis.

The purpose of this study is to identify and determine key factors, emerging trends and driving forces in the development of future faculty promotion regulations (FPR) and evaluate the structural relationship between key factors over the Horizon 2035. For this purpose, relying on a mixed methodology and using the literature review, interviews, the cross-impact analysis matrix, MicMac software and expert panels, key factors are identified and the relationship of influence and dependence between them are structurally analyzed. As a result, five forces including "Discourse governing higher education in Iran", "Society (industry, market and government) expectation of higher education", "Economics of higher education", "Competitiveness and internationalization of higher education" and "Emerging challenges and development of Interdisciplinary sciences" are considered as drivers of change in the subject of research and the function and influence of each in the future of the faculty promotion system is explained. Accordingly, upgrading future editions of FPR requires alignment with the identified drivers, considering structural complexities between key factors and adapting to changes in the social, economic and political environment through interdisciplinary and futuristic approaches.