muhammad ishfaq
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This study aims at evaluating the utilization of carbonate rocks from the Bampokha (Nikanai Ghar Formation) and Sawaldher (Kashala Formation) areas in different industries. Two varieties from the Nikanai Ghar Formation, known under the trade names as Super-white and Sunny-grey, are selected for petrographic and geochemical analysis to evaluate these as a source of calcite (CaCO3), in chemical industries. Petrographically, both the varieties from Bampokha area, are calcitic marbles that exhibit heteroblastic mosaic texture. Geochemical data coupled with X-ray diffraction and petrographic analysis confirms that the Super-white variety is very high purity marble and hence meets the specifications for different chemical industries such as iron and steel industry, glass manufacturing, flue gas desulphurization, soda ash manufacturing and water purification and effluent treatment. In contrast, the high silica (4.1 wt.%) and low calcite contents (<95 wt.%), render the Sunny-grey unsuitable for chemical industries. The rock from Sawaldher quarry, exhibiting an interlocking mosaic pattern, is calcitic marble. Minor amounts of quartz, muscovite and opaque minerals also occur. Comparing the physico-mechanical properties of the aggregate from Sawaldher marble with time-honoured international standards suggests its suitability in concrete work with ordinary portland cement and asphalt. The concrete mix, designed for Class D2 concrete, has an average 28-days compressive strength value of 518 kg/cm2 and thus well above the minimum targeted strength of 425 kg/cm2 for the mentioned class, and hence further endorses that the aggregate can produce strong concretes. This study also suggests the utilization of the studied carbonate resources on industrial scale.Keywords: Carbonates, Chemical industries, Aggregate properties, Concrete mix design, industrial scale
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The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties and are mainly found in the roots of Oroxylum indicum (L.) Kurz and Scutellaria baicalensis Georgi. These flavonoids have been reported to possess various pharmacological properties, including antibacterial, antiviral, anticancer, anticonvulsant, anti-oxidant, hepatoprotective, and neuroprotective effects. The pharmacological properties of baicalin and baicalein are due to their abilities to scavenge reactive oxygen species (ROS) and interaction with various signaling molecules associated with apoptosis, inflammation, autophagy, cell cycle, mitochondrial dynamics, and cytoprotection. In this review, we summarized the molecular mechanisms underlying the chemopreventive and chemotherapeutic applications of baicalin and baicalein in the treatment of cancer and inflammatory diseases. In addition, the preventive effects of baicalin and baicalein on mitochondrial dynamics and functions were highlighted with a particular emphasis on their anti-oxidative and cytoprotective properties. The current review highlights could be useful for future prospective studies to further improve the pharmacological applications of baicalein and baicalin. These studies should define the threshold for optimal drug exposure, dose optimization and focus on therapeutic drug monitoring, objective disease markers, and baicalin/baicalein drug levels.
Keywords: Baicalein, Baicalin, Cancer, Inflammatory diseases, Mitochondrial functions -
International Journal Of Nonlinear Analysis And Applications, Volume:12 Issue: 1, Winter-Spring 2021, PP 1057 -1071
In this paper we study the notion of Gerghaty type contractive mapping via simulation function along with $mathcal{C}$-class functions and prove the existence of several fixed point results in ordinary and partially ordered metric spaces. An example is given to show the validity of our results given herein. Moreover, existence of solution of two-point boundary value second order nonlinear differential equation is obtain.
Keywords: Simulation functions, C-class function, partially ordered metric space
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