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To determine the prevalence of various types of conjunctival lesions, at a tertiary ophthalmic center in Fars Province, South of Iran. Histopathologic slides and medical records of conjunctival lesions submitted to the pathology department of Khalili Hospital, Shiraz, Iran was reviewed from April, 2009 to July, 2013. The histopathologic diagnoses were categorized into benign, pre malignant, and malignant lesions. The prevalence of various types of conjunctival lesions was calculated. Histologic sections of 631 conjunctival lesions were reviewed. Benign lesions were most prevalent (81.8%), followed by premalignant (10.8%) and malignant (7.4%) lesions. Pterygia were the most common benign lesions (69.2%), intraepithelial dysplasia constituted most cases of premalignant lesions (94.1%), and squamous cell carcinoma was the most frequent malignant lesion (93.6%). Benign lesions were the most common type of lesions in all age groups; however the prevalence of malignant lesions increased significantly with age (P< 0.001). Benign lesions were the most common conjunctival lesions with pterygia on top of the list, while intraepithelial neoplasia and squamous cell carcinoma were the most common premalignant and malignant lesions, respectively. Conjunctival malignant lesions were more prevalent with older age.

BAKGROUND AND Routine diagnostic methods of Vesicoureteral reflux (VUR) are invasive and can cause exposure to radiation and may increase risk of urinary tract infections. Therefore, introducing reliable, non invasive methods might be more interested in pediatric nephrology. The objective of this perspective case control study was to evaluate the prognostic value of urinary neutrophil-gelatinase associated lipocalin (uNGAL) on antenatal hydronephrosis (AH) with and without VUR. MTERIALS AND A total of 50 patients diagnosed with AH; 78% males with mean age 5.71± 2.1 years, including 27 AH with VUR and 23 AH without VUR, and 19 normal healthy children; 78.9% males with mean age 5.63 ± 1.89 years, were enrolled in this study. Urinary NGAL levels were measured by enzyme linked immunosorbent assay (ELISA). There was a significant difference in uNGAL concentration between AH patients and controls (0.80 ± 0.26 and 0.29 ± 0.27 ng/ml, p<0.0001). However, the levels of uNGAL was not significantly deviated between AH patients with VUR compared to those without VUR (0.84 ± 0.34 vs. 0.75 ± 0.13, p=0.419). Standardization of NGAL based on urinary creatinine (uNGAL/uCr) showed a significantly difference between AH neonates with VUR compared to those without VUR (2.43±1.61 vs. 1.91±0.79, p<0.0001). Receiver operator characteristic (ROC) analysis revealed higher prognostic power of uNGAL for identifying AH with a sensitivity; 95.7%, and specificity; 84.2%. Meanwhile, the levels of uNGAL or NGAL/uCr ratio did not correlate with reflux grade or laterality. The urinary level of NGAL and NGAL/uCr ratio might be a surrogate non invasive, reliable tool to distinguish hydronephrosis.