paramasari dirgahayu

Malaria is an infectious disease caused by parasite Plasmodium sp., while infection with malaria can cause an excessive increase in free radicals and damage several organs. This study evaluated the effect of artemisinin-based combined therapy with Salacca edullis reinw (Zalacca) seed extract on malondialdehyde (MDA) level in micemalaria model. Using a post-test design randomized method, 48 male white mice were divided into 6 groups, including 2 control and 4 treatment groups, while they were inoculated with Plasmodium berghei ANKA. Follow-up was undertaken for 14 days when comparing the groups. Artemisinin and zalacca seed extract were used in treatment groups of malaria infection. The treatment with artemisinin and zalacca seed extract revealed a significant decrease in MDA level in mice infected to malaria. Zallaca seed extract was demonstrated to reduce MDA level in mice infected to malaria. Even administration of artemisinin alone could reduce the MDA level, but was not significant. Treatment with a combination of artemisinin and zallaca seed extract was shown to significantly lower MDA level in malaria infection.

Strawberry fruit has been studied to have a good effect on type 2 diabetes mellitus (T2DM). It has been demonstrated that interventions with various doses of strawberry fruit in preparations such as consumed intact, cooled, extracted and even processed in the powder can provide good benefits against T2DM and to improve insulin sensitivity, blood vessel inflammation and endothelial dysfunction and to reduce blood sugar. This review explains how the antioxidants in strawberries can directly affect type 2 diabetes mellitus biomarkers, especially in T2DM model mice and rats.