seyedeh fatemeh sajjadi
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سابقه و هدف
بین رفتار خواب و کیفیت ارائه خدمات در پرستاران ارتباط تنگاتنگی وجود دارد. ازآنجاکه پرستاران یکی از مهم ترین گروه های فعال در جهت تامین سلامتی بیماران می باشند، باید از وضعیت خواب مناسبی برخوردار باشند. پژوهش حاضر با هدف بررسی نقش باور معنوی و تنظیم هیجان در پیش بینی مشکلات بی خوابی در پرسنل پرستاری انجام گرفت.
روش کارروش پژوهش توصیفی و از نوع هم بستگی بود. جامعه آماری پژوهش شامل کلیه پرستاران شاغل در بخش های کرونایی بیمارستان های شهر شیراز در سال 1401 می شد، که از بین آن ها با روش نمونه گیری در دسترس تعداد 150 نفر انتخاب شدند. گردآوری داده ها با پرسش نامه «شدت بی خوابی» (مورین، 1993)، پرسش نامه «باور معنوی» (آلپورت و راس، 1967) و پرسش نامه «تنظیم هیجان» (گروس و جان، 2003) انجام شد. برای تحلیل داده ها آزمون هم بستگی پیرسون و رگرسیون گام به گام با نرم افزار آماری spss نسخه 26 به کار رفت و سطح معناداری 05/0 در نظر گرفته شد.
یافته هانتایج نشان داد که بین تنظیم هیجان با مشکل بی خوابی ارتباط منفی و معنی دار (62/0- =r و 018/0>P)، و بین باور معنوی با مشکل بی خوابی نیز ارتباط منفی و معنی داری وجود دارد (56/0- =r و 022/0>P). نتایج رگرسیون نیز حاکی از این بود که متغیرهای پیش بین، به طور همزمان توانستند 31 درصد از واریانس مشکلات بی خوابی را پیش بینی کنند (31/0=R2 و 007/0>P).
نتیجه گیریبراساس نتایج این پژوهش، افزایش مدیریت هیجانی و باور معنوی، عوامل مهمی در بهبود وضعیت خواب پرسنل پرستاری هستند.
کلید واژگان: خواب، باور معنوی، پرستاران، تنظیم هیجانBackground and ObjectiveThere is a close relationship between sleep behavior and service quality in nurses. Since nurses are one of the most important active groups in order to ensure the health of patients, they should have a good sleeping status. The present study was conducted with the aim of investigating the role of spiritual belief and emotion regulation in predicting insomnia problems in nursing personnel.
MethodsThe research method was descriptive and correlational. The statistical population of the research included all the nurses working in the corona departments of the hospitals of Shiraz city in 2022, out of whom 150 were selected by available sampling method. Data collection was done using Insomnia Severity Index (Morin, 1993), Religious Orientation Scale (Allport & Ross, 1967), and Emotion Regulation Questionnaire (Gross & John, 2003). For data analysis, Pearson's correlation test and step-by-step regression were performed with SPSS statistical software version 26. Significance level was considered to be 0.05.
ResultsThe results showed that there is a negative and significant relationship between emotion regulation and insomnia (r=-0.62 & p<0.05), and there is a negative and significant relationship between spiritual belief and insomnia (r=-0.56 & p<0.05). The regression results also indicated that predictive variables could simultaneously predict 31% of the variance in insomnia problems (R2=0.31 & P<0.007).
ConclusionBased on the results of this research, increasing emotional management and spiritual belief are important factors in improving the sleep status of the nursing personnel.
Keywords: Emotion Regulation, Nurses, Sleep, Spiritual Belief -
Background
Worldwide, aggression is one of the main death causes for people between the ages of 15 to 44. Understanding the risk factors may be critical to accurate aggression and treatment.
ObjectivesThis study aimed to examine the relation between early traumatic events, callous-unemotional traits and insecure attachment style with aggression in a sample of adolescent out-patient.
MethodsAsample of high school students (n=345) with a mean age of 16.62 (SD=0.81) years completed Boss and Perry Aggression Questionnaire (BPAQ), Early Trauma Inventory (ETI), Inventory of Callous-Unemotional (ICU) traits and revised adult attachment scale (RAAS). The obtained data were analyzed using Pearson correlation coefficient and multivariate regression analysis.
ResultsRegression analysis revealed that 13% variance of aggression can be predicted by early traumatic events, insecure style of attachment and callous-unemotional traits.
ConclusionOur findings provide further insight into the role of particularpsychopathy traits, trauma and attachment in developing and maintaining aggression. Study implications and limitations are considered.
Keywords: Aggression, Callous-unemotional traits, Insecure attachment, Trauma -
آترواسکلروز یک بیماری عروقی مزمن و عامل اصلی مرگ و میر در سراسر جهان می باشد. اختلال در عملکرد سلول های اندوتلیال عامل مهمی در ایجاد آترواسکلروزیز می باشد. افزایش بیان ژن های شاخص چسبندگی سلولی و کاهش پروتئین های متصل کننده سلول ها منجر به عملکرد غیرطبیعی اندوتلیوم می شود. این تغییرات مولکولی از مهمترین نشانگرهای اختلال در سلول های اندوتلیال و پیشرفت بیماری آترواسکلروز می باشد. CXCR3 یک گیرنده کموکاینی G پروتئینی است که توسط سلول های اندوتلیال بیان می شود. نقش گیرنده CXCR3 و لیگاندهایش در عملکرد سلول های اندوتلیالی و ایجاد بیماری های قلبی هنوز به درستی شناخته نشده است. در این مطالعه تاثیر کاهش بیان ژن CXCR3 بر میزان بیان نشانگرهای چسبندگی (I-CAM-1 ، V-CAM-1) و اتصال محکم (TJP1) بین سلولی مورد بررسی قرار گرفت. به منظور کاهش بیان ژن CXCR3 از DNAzyme برش دهنده بر علیه mRNA ژن CXCR3 استفاده شد. DNAzyme توسط توربوفکت به درون سلول های HUVEC ترانسفکت شد. بعد از تایید کاهش بیان ژن CXCR3، استخراج RNA و سنتز CDNA انجام شد و سپس بیان ترانسکریپت ژن های هدف توسط تکنیک RT-qPCR مورد ارزیابی قرار گرفت. نتایج بدست آمده نشان داد که سطح بیان ICAM-1 وVCAM-1 به طور قابل توجهی در سلول های ترانسفکت شده در مقایسه با سلول های کنترل افزایش یافت در حالی که ژن TJP1 تغییر قابل توجهی نشان نداد. به نظر می رسد که کاهش بیان ژن CXCR3 می تواند زمینه ساز ایجاد اختلال در عملکرد سلول های اندوتلیالی از طریق افزایش بیان مولکول های چسبندگی شود. بنابراین، این گیرنده می تواند به عنوان یک هدف مولکولی بالقوه برای درک بهتری از مکانیسم ایجاد بیماری آترواسکلروز در نظر گرفته شود.
کلید واژگان: آترواسکلروز، اختلال عملکرد اندوتلیال، CXCR3، اتصالات محکم، نشانگرهای چسبندگیAtherosclerosis is a chronic vascular disease and remains the leading cause of death and morbidity worldwide. Endothelial dysfunction is an important factor in the progression of atherosclerotic disease. Increased expression of cell adhesion index genes and decreased cell-binding proteins lead to abnormal endothelial function. These molecular changes are one of the most important indicators of endothelial cell dysfunction and the progression of atherosclerosis. CXCR3 is a G-protein-coupled chemokine receptor expressed by endothelial cells. The role of the receptor CXCR3 and its ligands in endothelial cells and heart disease is not yet fully understood. In this study, we evaluated the effect of CXCR3 downregulation on the expression level of adhesion (I-CAM-1, V-CAM-1), tight junction (TJP1), related to endothelial dysfunction.In order to reduce the expression of the CXCR3 gene, the RNA-cleaving DNAzyme was used against the mRNA of the CXCR3 gene. DNAzyme was transfused into HUVEC cells by TurboFectTM. After confirmation of decreased CXCR3 gene expression, RNA extraction and cDNA synthesis were performed and then the expression of markers was evaluated by RT-qPCR technique.Our result was showed the expression level of I-CAM-1 and V-CAM-1 were showed significant up-regulation in transfected cells compared with control cells, while the TJP1 gene was not showed significant change. It seems that reducing the CXCR3 gene expression could induce endothelial dysfunction through the change of adhesion markers genes expression. Therefore, this receptor can be considered as a potential molecular target for a better understanding of the mechanism of atherosclerosis.
Keywords: Atherosclerosis, Endothelial dysfunction, CXCR3, Tight junction, Adhesion markers -
BackgroundResearch evidence shows that exercise is associated with positive physical and mental health. Moreover, exercise and wheel running in rats activate overlapping neural systems and reward system. The most commonly used models for the study of rewarding and aversive effects of exercise involve using treadmill and wheel running paradigms in mice or rats. The purpose of our experiment was to study the influence of continuous voluntary exercise on exercise-seeking behavior.MethodsIn this experimental study, we used 24 adult male SpragueDawley rats weighing 275300 g on average. Rats were divided into 3 experimental groups for 4 weeks of voluntary wheel running. Each rat ran in the cage equipped with a wheel during 24 hours. A within-subject repeated measure design was employed to evaluate the trend of running and running rates.ResultsWe found that time and higher levels of exercise will increase exercise tendency. Our results also show that the interaction of exercise within 4 weeks and different levels of exercise can significantly promote rats exercise-seeking behavior (F = 5.440; df = 2.08; PConclusionOur data suggest that voluntary wheel running can increase the likelihood of extreme and obsessive exercising which is a form of non-drug addiction.Keywords: Exercise, Non-drug addiction, Rats, Running wheels
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BackgroundBorderline personality (BP) is a serious mental condition in clinical practice which is marked by aggression and is shown to be affected by traumatic life events.ObjectivesThis study aimed to determine the relationship between early trauma and aggressive traits as predictive factors of borderline personality features (BPF) in high school students.MethodsThree hundred and eleven students with mean age of 16.66 were recruited via multi stage random sampling. All the participants were asked to complete borderline personality features scale for children, early trauma inventory, and buss-perry aggression questionnaire. Analyzing data was done using canonical correlation.ResultsThe results indicated that BPF is predicted by early trauma and aggression traits.ConclusionsIn general, the findings showed that early trauma, physical aggression, verbal aggression, anger, and hostility can predict BPF and explain a considerable variance of survival index.Keywords: Borderline Personality Disorder, Trauma, Aggression, Students
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BackgroundAddiction is described as a condition in which individuals are not able to control their drug use despite long-term negative consequences. Non-drug addiction or behavioral addiction such as exercise can mimic similar physiological changes in the brain and reward circuit enhancement. Psychological dependence of drug abuse, which is characterized by drug seeking behaviors will develop an ongoing cycle of drug withdrawal and relapse. Moreover, exercise has two bimodal effects; it may decrease drug seeking in a physiologic range and it may increase drug seeking when it is taken in large quantity. The current study aimed to investigate and compare the effects of voluntary and compulsory exercise on male rats tendency towards using morphine..MethodsWe included 32 male rats that were 2 months of age. After 2-weeks of compulsory and voluntary exercise, all rats were exposed to 5-day conditioned place preference (CPP) in order to evaluate drug-seeking behavior. The CPP scale was obtained by comparing the data from pre-conditioning and post-conditioning phases and it was used to evaluate morphine-dependence..ResultsThe results of the current study showed that the rats that received compulsory exercise had significantly less tendency towards morphine (PConclusionsWe conclude that compulsory exercise may reduce psychological dependence on morphine and could also be regarded as a proper complementary method for addiction prevention and preventing relapse..Keywords: Compulsory Exercise, Voluntary Exercise, Conditioned Place Preference, Morphine, Rat
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