t. guo

To investigate the use of uniportal video-assisted thoracoscopic surgery (U-VATS) in the treatment of non-small cell lung cancer (NSCLC).

A total of 82 patients with early NSCLC in our hospital from May 2019 to January 2021 were enrolled to this study. Forty-one patients treated with spontaneous breathing U-VATS were the research group (RG), and 41 with conventional thoracoscopy were the control group (CG). Fasting peripheral blood was drawn from patients before (T0), one (T1) and three days after surgery (T2), respectively. White blood cells (WBC), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), matrix metalloproteinase-9 (MMP-9) and T-lymphocyte subsets were measured in the blood. In addition, we counted the conversion rate to open chest and tracheal intubation in the RG, and compared the operation time, intraoperative bleeding, chest drainage, chest tube retention time, antibiotic application time, postoperative hospital stays and complications between groups. Finally, a 1-year prognostic follow-up was performed to record overall survival, chemotherapy rate, and recurrent metastasis rate.

At T1, WBC, IL-6, TNF-α, and MMP-9 were lower in the RG than in the CG, while immune function was better in the RG at T1 and T2 (P<0.05). Complication rates were lower in the RG than in the CG when compared (P>0.05). The prognosis of 1-year overall survival, chemotherapy rate, and recurrence rate were not different between the two groups (P>0.05).

Spontaneous breathing U-VATS can effectively reduce the inflammation and enhance the stability of immune function in NSCLC patients undergoing surgery.

Vibration and fatigue damage of pump shafts has become a prominent engineering problem, indicating the need for higher-quality reliability analysis of the pump unit in the design stage. In this study, the unsteady flow field in a large centrifugal dredge pump was numerically simulated via the unsteady Reynolds-averaged Navier-Stokes (URANS) method with the SST k-ω model. An experiment was carried out to verify the numerical method. The hydraulic radial force on the impeller and the total radial load were calculated based on computational fluid dynamics. The flow field with a double volute was simulated, analyzed, and compared to the flow field with a single volute. The stress of the pump shaft caused by the radial load was also calculated and discussed. The results show that the impeller gravity determines the time-averaged value and fluctuation frequency of the total radial load on the shaft, which must be considered in the shaft stability analysis. The total radial load fluctuating in asymmetric cycle results in stress cycles with different features at different circumferential locations. The application of a double volute effectively reduces the radial load on the pump shaft, which decreases the time-averaged hydraulic radial force by 38% and its fluctuation amplitude by 3%, decreases the time-averaged total radial load by 20% and its fluctuation amplitude by 28% in the design condition, and decreases the local stress at the narrowest shaft section by 44%. A double volute can be applied to weaken vibration and fatigue damage for a pump shaft if it is acceptable for the pump efficiency to be lowered.