Effect of Fumaria Parviflora hydro alcoholic extract on induced carageenan inflammation in male rat paw

This study investigated the anti-inflammatory effect of Fumaria Parviflora due to its Fumaric acid، flavonoid and phenolic compounds for skin diseases، relieves itching and eczema. Male wistar rats (ranging 150-180g in weight) were used. For preparation of the hydro alcoholic extract، Plant powdered were macerated in ethanol 70%، then extract were concentrated for further use. Five treatment Animal groups received dose of 200، 400، 600، 800 or 1000 mg/kg of Fumaria Parviflora extract، Positive control group received a dose of 300 mg/kg aspirin and negative control group received serum physiology solution with dose of 5 ml/kg via intra-peritoneal injection of traits. After half an hour، 100 micro liters of carageenan 1%was subcutaneously injected into the rat’s paw and then the volume of the rat’s paws were evaluated using PLethysmometer apparatus. once every hours between the first and fifth hours 200 and 400 mg/kg doses of extract had less effect on decreasing the paw’s edema in comparison with animal group received aspirin (p<0. 05). However، dose of 600، 800 and 1000 mg/kg of the extract had more effects on decreasing the paw’s edema، but difference between two groups is not statistically significant (p>0. 05). Fumaria parviflora hydro alcoholic extracts with doses of 600، 800 and 1000 mg/kg and aspirin (300 mg/kg) significantly decreased the paw’s edema in the subject field rats compared to group received 5ml/kg of Serum physiology solution. Moreover، as the fewer side effects are to be expected for lower dose of 800 mg/kg; the most appropriated dose was selected for this extract. Using complimentary examinations in toxicity of this extract it could be used to decrease the inordinate intake of NSAIDs.