The Association between Anthropometric Measurements and Homocysteine Levels

Recent studies have shown that obesity and inappropriate level of anthropometric measurements could be correlated to hyperhomocysteinemia. So، this study aimed to assess the probable association between different anthropometric measurements with serum homocysteine levels. This cross-sectional study was conducted on 107 migraine patients who referred to Isfahan Korshid and Imam Mosua Sader clinics in 2013. Anthropometric measurements such as weight، height، Body Mass Index (BMI)، Body Fat Mass (BFM)، Lean Body Mass (LBM)، Waist Circumference (WC)، Waist-Hip Ratio (WHR) and Waist-Height Ratio (WHtR) were measured for each patient. Also fasting homocysteine concentration was assessed from all patients by ELISA. Data analysis was conducted by SPSS18 software using descriptive (mean and standard deviation) and analytic (t-test، X2 and regression) statistic tests. The mean of patients’ age in men and women was 36±12. 3 and 33. 8±10. 7 years، respectively. The findings showed that 11. 7% of men and 21. 1% of women suffered from hyperhomocysteinemia. Based on the results، a significant positive association was found between BMI، BFM، WC، WHR and WHtR، with serum homocysteine levels in total population and in both genders (P<0. 05). In addition، patients with high LBM had high serum homocysteine concentration (P<0. 001); however’ sex-stratified analysis revealed no significant relationship between LBM and serum homocysteine levels either in men or women. This study revealed a positive and significant relationship between BMI، BFM، LBM، WC، WHR and WHtR (as indices of central and general obesity) with serum homocysteine level.