Association of Microalbuminuria and Estimated Glomerular Filtration Rate With Carotid Intima-Media Thickness in Patients With Type 2 Diabetes Mellitus

Atherosclerosis is the main cause of cardiovascular diseases, and its risk enhances in type 2 diabetes mellitus.. This study aimed to evaluate Carotid Intima-Media Thickness (CIMT) by carotid artery ultrasonography and assess its correlation with microalbuminuria and estimated Glomerular Filtration Rate (eGFR) in the patients with type 2 diabetes mellitus..Patients and This cross-sectional study was included 205 patients with Type 2 Diabetes Mellitus (T2DM). We recorded clinical and biochemical data such as FBS, lipid profile, and urinary albumin. Intima-media thickness of carotid arteries was measured in all patients by high frequency ultrasound.. In simple correlation coefficients analysis, CIMT was significantly associated with total cholesterol (r = 0.197, P = 0.008), serum creatinine (r = 0.240, P = 0.001), and urinary albumin (r = 0.420, P = 0.000). Also, CIMT elevated significantly with the stage progression of chronic kidney disease (0.67 ± 0.15 mm in stage 1, 0.73 ± 0.22 mm in stage 2, and 0.82 ± 0.21 mm in stage 3) (P value = 0.024). In multivariate linear regression analysis, the duration of diabetes, weight, HDL, serum creatinine, urinary albumin, and estimated Glomerular Filtration Rate (eGFR) were independently associated with CIMT (P value < 0.05 for all).. Our study shows a relationship between CIMT and renal parameters, including eGFR and albuminuria. This study confirms the importance of intensive examinations for early detection of atherosclerosis and treatment of risk factors..