Experimental and Clinical Evaluation of Plantago australis Extract as an Anti-Inflammatory Agent to Treat Oral Pathologies

Plantago australis is a native plant from Southern Brazil used to reduce inflammation. Interestingly, there are no previous studies evaluating its use to treat oral lesions..
The study aimed to investigate in vivo the anti-inflammatory activity of 10% ethanol extract of P. australis in recurrent aphthous stomatitis (RAS), erosive lichen planus (ELP) and actinic cheilitis (AC)..
Thirty patients with RAS, ELP and AC were treated topically with 10% P. australis solution-based or cream..
In the comparison of in vivo data before and after the treatment and between different lesions, all P values were less than 0.05..
The pharmaceutical formulation of 10% P. australis was therapeutically effective in the subjects with inflammatory oral lesions of RAS, ELP and AC..