Vitamin D receptor gene polymorphisms and cardio-metabolic profile in women with hypovitaminosis D

The possible role of vitamin D receptor (VDR) variants in determining cardiovascular risk factors has been suggested previously. The purpose of the present study was to evaluate the associations of variants of vitamin D receptor (VDR) gene with metabolic profile in Iranian overweight women with hypovitaminosis D. Variants in VDR gene including FokI (rs2228570), BsmI (rs1544410) and rs757343 were detected using PCR-sequencing. Metabolic Profile including fasting plasma glucose, total cholesterol, LDL-C, HDL-C, and triacylglycerol was assessed using commercial kits. Circulating 25 (OH) D was measured using ELISA kits. Fat mass and visceral fat were measured using Bio Impedance Analysis. A sample of 123 overweight women with hypovitaminosis D (25 (OH) D0.05). Also, adiposity phenotype measures were not significantly different in the genotype groups of the studied SNPs (p>0.5). The present results indicate that the FokI polymorphism is significantly associated with total cholesterol and LDL-C in Iranian overweight women with hypovitaminosis D.