Antibiotic Resistance Patterns and Molecular Typing of Acinetobacter Baumannii Strains Isolated from Burn Patients in Iran
Author(s):
Article Type:
Research/Original Article (بدون رتبه معتبر)
Abstract:
Background and Aims
Acinetobacter baumannii (A. baumannii) is an important multidrug-resistant opportunistic pathogen frequently causing various nosocomial infections and is a serious threat to burn patients. These infections are usually caused by the outbreak strains. The aim of this study was to show antibiotic resistance pattern and molecular typing of A. baumannii genes isolates collected from burn patients and also distribution of different types of burn patients.
Materials and Methods
In this study, 307 different strains were detected. Totally 100 A. baumannii strain was selected in burn center of Isfahan hospital. Antibiotic resistance pattern was determined by disk diffusion method (Kirby Bauer). The presence of genes coding in antibiotic resistance were analyzed by using multiplex-PCR method. The standard strains of Escherichia coli ATCC 25922 and A. baumannii ATCC 19606 were used as negative and positive controls.
Results
The antibiotic resistance pattern for A. baumannii showed high resistance for ciprofloxacin, ceftazidime, and tetracycline with frequency of 82.5%, 75.3%, 72%, respectively. Moreover, the most sensitive antibiotics were chloramphenicol, and nitrofurantoin with the resistance frequency of 3.9% and 2.8%. CITM (91.1%) was the highest detected gene.
Conclusions
High prevalence of antibiotic resistance pattern among A. baumannii isolated from burn center hospitals indicates the important role of multidrug resistant isolates. Keywords:
Language:
English
Published:
International Journal of Medical Laboratory, Volume:5 Issue: 4, Nov 2018
Pages:
278 to 287
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