The effect of endurance exercise and adenosine consumption on the a1ar gene expression in the visceral adipose tissue of obese male rats

Angiopoietin-like proteins that be involved in the regulation of lipid metabolism, can be potentially utilized in therapies for metabolic syndrome. The purpose of this study was to investigate the effect of eight weeks intermittent and continuous exercise training on serum angiopoietin-like protein 8 levels and lipid profile in 9-11 years old obese girls. Thirty students aged 9 to 11 years old with a percentile of body mass index more than 90% were randomly assigned to control (n = 9), continuous training (n = 11), and intermittent exercise (12). The exercises included eight weeks of continuous and intermittent walking (3 sessions per week). The subjects underwent continuous training in the first four weeks with 60-75% HRmax and in the second four weeks with of 70-75% HRmax, and subjects with intermittent exercises in the first four weeks with intensity of 75-80% HRmax and in the second four weeks with of 80-85% HRmax. Serum levels of ANGPTL8, HDL, LDL, TG, TC and glucose was measured in pre-test and post-test. The results of this study showed that in the intermittent group, ANGPTL8, TC, glucose increased (p< 0.05), and BMI and percentile of body mass index decreased (p<0.05). In the continuous group, the levels of ANGPTL8 and TC increased (p< 0.05) and BMI decreased (p<0.05). Comparison between groups showed that glucose and ANGPTL8 were not significantly different in two groups. The increased of angiopoietin-like protein 8 after eight weeks of continuous and intermittent exercises was independent of the type of exercise. It seems that, one of the main reasons  is the increase of glucose and TC, which suggests the therapeutic potential of angiopoietin-like protein 8 in reducing these factors by inhibiting it.