Relationship between Serum Levels of Anti-Mullerian Hormone, Adiponectin and Oxidative Stress Markers in Patients with Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Anti-Muller hormone (AMH) is a valid indicator of ovarian function and PCOS diagnosis. Some studies have shown that adipokines are effective in the synthesis of AMH, and a relationship would have existed between them. The aim of present study was to determine the relationship between serum levels of anti-Mullerian hormone, adiponectin and other related factors in PCOS patients.

In this cross-sectional study, PCOS and healthy women (80 cases) were investigated. Serum levels of AMH, adiponectin, gonadotropins, androgens, insulin resistance, total antioxidant capacity and nitric oxide (NO) measured by standard methods. Independent T-test was used to compare two groups and Pearson correlation coefficient was used to determine the relationship between variables.

There was a significant difference between the mean of AMH (5.16±5.3 vs 2.44±2.5 ng/mL) (P=0.007) and adiponectin (24.55±9.41 vs 30.57±14.2 µg/L) (P=0.029) among PCOS and control group respectively. The correlation between AMH and adiponectin in control group was statistically significant and negative (P = 0.028, r = -0.35), while that of PCOS group was not significant (P=0.113, r=-0.25).

Various biochemical and hormonal factors differ between PCOS and normal women. Different factors can impudence AMH and adiponectin levels independent of PCOS in women of reproductive age.