Is Vitamin C or HAT Therapy Effective in Treating Sepsis? A Mini Review

One of the most common causes of mortality in critical patients admitted to the intensive care unit (ICU) is sepsis. In recent years, the administration of high doses of vitamin C and HAT (hydrocortisone, ascorbic acid and thiamine) therapy has attracted much attention in patients with sepsis.

The current article reviews the beneficial effects of HAT therapy in light of research conducted in this area.

A general search for electronic databases was developed. The human studies of the influence of HAT therapy in critically ill patients were evaluated.

The results indicated that HAT therapy may improve clinical outcome in septic patients; however, widespread use of these therapeutic approaches in sepsis requires large clinical trials in order to more confidently recommend this therapeutic approach in septic patients admitted to intensive care units.

HAT therapy may improve clinical outcome in septic critically ill patients.