Pathogenic characteristics of Th17 cells based on IL-17 signaling pathway in regulation of sebaceous gland lipoprotein metabolism in acne rat model

Acne is a common and chronic inflammatory dermatosis of human hair follicle sebaceous gland units. Acne is closely related to immune cytokines and cells including T reg cells (Th17 cells). Mis-regulated glycolipid metabolism also has a vital role to play in the process.

This investigation aims to explore the role of IL-17 in signaling pathways controlling sebaceous gland lipoprotein metabolism in rat model of acne.

We have performed experimental studies, generated the rat ear acne model, and have investigated the pathological changes of acne skin tissue by histological analysis and the changes of critical factors including DEFB1, GPR65, FADS1, and FADS2 by Western Blot in acne rat model.

There were more Th17 cells in the rat ear acne model than in the control mice. The expression levels of DEFB1, GPR65, FADS1, FADS2 and MOGAT1 were significantly upregulated in serum and tissue from rat acne models, which indicated that Th17 cells play a major role in the occurrence of acne based on the IL-17 signal pathway.

Although acne is associated with immune effects and glycolipid metabolism, inhibition of IL-17 signaling pathway might be a novel way for acne therapy. Our findings also suggest a new target therapy strategy for acne.