A sensitive electrochemical sensor based on multiwall carbon nanotube-ionic liquid/nickel oxide nanoparticles for simultaneous determination of the antipsychotic drugs clozapine and sertraline

In this report, a glassy carbon electrode (GCE) modified with multi-walled carbon nanotube (MWCNT), ionic liquid (IL) and nickel oxide nanoparticles NiO NPs has been introduced for the simultaneous determination of clozapine (CLOZ) and sertraline (SER) as antipsychotic drugs in biological fluids and pharmaceutical formulation using differential pulse adsorptive stripping voltammetric (DPAdSV) technique. The MWCNT-IL/NiONPs modifier catalyzed the oxidation of both drugs and enhanced the sensitivity of the resulted electrode for CLOZ and SER monitoring. The response of the electrode to CLOZ and SER oxidation were linear over the concentration ranges of 0.5 – 67 µM and 0.21 – 85 µM (R2>0.99), respectively. The detection limits of 0.052 and 0.047 µM were obtained for CLOZ and SER, respectively. The proposed electrochemical sensor exhibited a high sensitivity, good selectivity, and was successfully used for simultaneous determination of CLOZ and SER in real samples.