Role of Non-coding RNA as a Biomarker of Response to Therapeutic Agents in Colorectal Cancer

Chemoresistance is a severe drawback to the successful and effective treatment of colorectal cancer (CRC). Comprehensive molecular mechanisms of chemoresistance facilitate the development of effective therapeutic strategies to overcome chemoresistance in CRC. The dysregulation of several non-coding RNAs was related to chemoresistance in CRC. Considering the importance of lncRNAs and miRNAs as prognostic and response to treatment biomarkers, this review focuses on the role of miRNAs and lncRNAs in CRC chemoresistance. Non-coding RNAs have an essential role in tumor progression, metastasis, and CRC chemoresistance. Thus, miRNAs and lncRNAs can be used to respond to therapeutic biomarkers in CRC.